Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society1995
Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 1995Trial
- The Management of Parkinson's Disease Before, during and after Pregnancy-an MDS Scientific Issues Committee Review.Movement disorders clinical practice · 2026Review
- Review
- The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Journal of personalized medicine · 2024Article
- Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions.Journal of neurology · 2023Review
- Management of Orthostatic Hypotension.Continuum (Minneapolis, Minn.) · 2020Review
- Orthostatic Hypotension in Parkinson Disease.Clinics in geriatric medicine · 2020Review
- Management of Orthostatic Hypotension in Parkinson's Disease.Journal of Parkinson's disease · 2020Review
- Impaired orthostatic blood pressure stabilization and reduced hemoglobin in chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- The Pharmacology of Autonomic Failure: From Hypotension to Hypertension.Pharmacological reviews · 2017Review
- Pure Autonomic Failure.Current neurology and neuroscience reports · 2016Review
- Current pharmacological management of hypotensive syndromes in the elderly.Drugs & aging · 2015Review
- Droxidopa in neurogenic orthostatic hypotension.Expert review of cardiovascular therapy · 2015Article
- Current treatments in familial dysautonomia.Expert opinion on pharmacotherapy · 2014Review
- Neurogenic orthostatic hypotension in Parkinson's disease: evaluation, management, and emerging role of droxidopa.Vascular health and risk management · 2014Review
- Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management.Journal of neurology · 2013Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemia is a common complication of autonomic failure and reduced red blood cell mass may contribute to the orthostatic hypotension of these patients. We investigated whether treatment with recombinant erythropoietin improves anemia and increases blood pressure in patients with primary autonomic failure. Three patients with multiple system atrophy and autonomic failure and one with pure autonomic failure were studied. All patients had normocytic normochromic anemia and low (n = 2) or normal (n = 2) serum levels of erythropoietin. Treatment with erythropoietin, 4000 U subcutaneously biweekly for 6 weeks, increased hematocrit and blood pressure in all patients. Hematocrit increased from 33.9 +/- 0.7 to 44.3 +/- 1.4%, blood pressure in supine position increased from 150 +/- 8/87 +/- 8 (systolic/diastolic; mean +/- SD) to 166 +/- 25/92 +/- 12 mmHg, and after 3 min in the head-up tilt position from 86 +/- 21/47 +/- 15 to 102 +/- 23/63 +/- 12 mmHg, (p < 0.05). All patients reported improvement in orthostatic symptoms and increased tolerance to standing. The study shows that treatment with erythropoietin improves anemia, increases blood pressure and ameliorates orthostatic hypotension in patients with primary autonomic failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.