ArticleBritish journal of cancer1995
Expression of fibroblast growth factor 1 is lower in breast cancer than in the normal human breast.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Synthesis and biological evaluation of esterified anti-inflammatory drugs with ethylene glycol linkers: cytotoxicity, anti-inflammatory and antioxidant properties.Royal Society open science · 2025Article
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- Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer.British journal of cancer · 2002Article
- Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas.Journal of clinical pathology · 2001Article
- Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors.Breast cancer research : BCR · 2000Review
- Article
- Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaffin cells and related gastrointestinal tumours.Virchows Archiv : an international journal of pathology · 1997Article
- Expression of keratinocyte growth factor and its receptor in human breast cancer.British journal of cancer · 1997Article
- The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue.British journal of cancer · 1997Article
- Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance.British journal of cancer · 1997Article
- The role of angiogenic growth factors in breast cancer progression.Cancer metastasis reviews · 1996Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have measured the amount of fibroblast growth factor 1 (FGF-1) mRNA and protein in primary breast cancers and non-malignant breast tissue and have found greatly reduced levels in breast cancer compared with non-malignant tissue. A total of 116 breast cancers and 37 biopsies taken from non-malignant breast were compared for FGF-1 mRNA expression using reverse transcriptase-polymerase chain reaction (RT-PCR) and significantly lower levels were found in the cancer tissues (P < 0.001). These findings were confirmed at the protein level where four out of five breast cancers contained no detectable FGF-1 and a fifth cancer had a low level of FGF-1 compared with three samples from reduction mammoplasties. Similar results were obtained from breast cell lines in which 80% of cancer cell lines had very low levels of FGF-1, whereas all non-malignant breast cell lines contained higher levels of FGF-1. Immunohistochemical analysis indicated that FGF-1 was present in the luminal epithelial cells of the non-malignant breast but was absent from cancer cells. The decreased levels of FGF-1 in breast cancer may indicate that stimulation of cancer cells is resulting in down-regulation of FGF-1 expression or may implicate FGF-1 as a differentiation factor rather than a growth factor at its physiological concentration in the breast.
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