ArticleAntimicrobial agents and chemotherapy1993
9-Anilinoacridines as potential antileishmanial agents.
Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Synthesis, Biological Evaluation, Molecular Dynamics, and QM-MM Calculation of Spiro-Acridine Derivatives Against Leishmaniasis.Microorganisms · 2025Article
- Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Synthesis of novel Eu(III) luminescent probe based on 9- acridinecarboxylic acid skelton for sensing of ds-DNA.Journal of fluorescence · 2012Article
- Synthesis and anti-intestinal nematode activity of variously substituted benzonaphthyridine derivatives.Molecules (Basel, Switzerland) · 2011Article
- Microscopic observation of progressive immobilization of leishmania promastigotes in acridine orange stain.Journal of clinical microbiology · 1997Article
- Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi.Antimicrobial agents and chemotherapy · 1996Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of 1'-substituted 9-anilinoacridines were evaluated for their activities against promastigote and amastigote forms of Leishmania major and for their toxicities to human Jurkat leukemia cells. Several compounds possessing 1'-NH-alkyl substituents produced more than 80% growth inhibition of macrophage-infected L. major amastigotes at or below a concentration of 1 microM. 1'-Hexylamino-9-anilinoacridine (compound 14) was the least toxic compound to human Jurkat cells, while it retained strong antileishmanial activity. There was a general trend for the more lipophilic compounds to show the greatest antileishmanial activity, whereas 3,6-di-NH2 substitution of the acridine nucleus reduced or eliminated activity. Some structure-activity relationships of the various compounds are discussed.
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Registered trials
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