ArticleProceedings of the National Academy of Sciences of the United States of America1993
Increased expression of apolipoprotein genes accompanies differentiation in the intestinal cell line Caco-2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005183 (Apolipoprotein A-I Gene Polymorphism and Atherosclerosis), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis
Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Trimethylamine increases intestinal fatty acid absorption:Journal of nutritional science · 2023Article
- Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies.iScience · 2022Article
- Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer.Molecular medicine reports · 2020Article
- Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis.Clinical and translational gastroenterology · 2019Article
- HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.The American journal of pathology · 2015Article
- Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Fibrillar collagen type I stimulation of apolipoprotein B secretion in Caco-2 cells is mediated by beta1 integrin.Biochimica et biophysica acta · 2009Article
- Article
- Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development.Medical hypotheses · 2007Review
- Apolipoprotein E knockout mice have accentuated malnutrition with mucosal disruption and blunted insulin-like growth factor I responses to refeeding.Nutrition research (New York, N.Y.) · 2006Article
- Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene.The Journal of clinical investigation · 1997Article
- Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.Molecular and cellular biology · 1997Article
- Lipid, apolipoprotein, and lipoprotein synthesis and secretion during cellular differentiation in Caco-2 cells.In vitro cellular & developmental biology. Animal · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have analyzed determinants of the synthesis and secretion of apolipoproteins including mRNA for apolipoproteins, in the human colon carcinoma cell line Caco-2 during differentiation in continuous culture. Significant increases in both cellular and secreted apolipoprotein A-I were observed early in the differentiation process. Increases in apolipoprotein B were limited to secreted protein and started later in the differentiation process. Levels of mRNA for apolipoproteins A-I, A-IV, B, C-III, and E increased significantly between the time cells reached confluence and 1 week postconfluence. The kinetics of mRNA accumulation were influenced by culture conditions. Nuclear extracts from postconfluent Caco-2 cells contained increased amounts of protein that bound to oligonucleotides containing the control regions of the apolipoprotein A-I and B genes. A competition experiment suggested that this protein recognized the control regions of both genes. We propose to name this protein DRIFT-1 (differentiation-related intestinal factor for transcription 1).
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