Evidence map›Paper›PMID 8516305›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1993

Unusual charge configurations in transcription factors of the basic RNA polymerase II initiation complex.

S Karlin

Abstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  9. Review
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  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

S KarlinDepartment of Mathematics, Stanford University, CA 94305.

Funding

THEORY &APPLIED STUDIES IN EVOLUTIONARY GENETICSR01GM010452 · NIGMS · STANFORD UNIVERSITY · PI KARLIN, SAMUEL · 1985 to 2006
$2.1M
MOLECULAR SEQUENCE DATAR01HG000335 · NHGRI · STANFORD UNIVERSITY · PI KARLIN, SAMUEL · 1990 to 2001
$449k
NHGRI NIH HHS 8R01HG00335-06NIGMS NIH HHS 5R01GM10452-29
6 · The paper itself

Abstract

A systematic analysis of the primary sequences of the polymerase II initiation complex has revealed unusual charge features in the TFII family proteins. In particular, the proteins TFIIA alpha, TFIIE alpha, and TFIIF carry multiple charge clusters and hyper charge runs, sequence features occurring in < 4% of all (available) eukaryotic proteins. Possible implications for these charge structures are discussed in relation to the assembly and function of the polymerase II transcriptional complex.

Indexed as

Transcription Factors, TFIIAmino Acid SequenceAnimalsConserved SequenceHumansMacromolecular SubstancesMiceMolecular Sequence DataProtein ConformationRatsRNA Polymerase IISaccharomyces cerevisiaeSequence Homology, Amino AcidTranscription FactorsTranscription Factor TFIIAMacromolecular SubstancesRNA Polymerase IITranscription FactorsTranscription Factors, TFIITranscription Factor TFIIAtranscription factor TFIIEtranscription factor TFIIF

Identifiers

PMID8516305
PMCPMC46767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.