ArticleProceedings of the National Academy of Sciences of the United States of America1993
Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.Nucleic acids research · 2012Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- YY1 is autoregulated through its own DNA-binding sites.BMC molecular biology · 2009Article
- The Yin and Yang of YY1 in the nervous system.Journal of neurochemistry · 2008Review
- NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes.Molecular and cellular biology · 2007Article
- Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.Molecular and cellular biology · 1999Article
- The role of c-myc in cellular growth control.Oncogene · 1999Review
- Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1.Nucleic acids research · 1998Article
- Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.Molecular and cellular biology · 1998Article
- Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1.Molecular and cellular biology · 1996Article
- Adenovirus E1A243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter.Journal of virology · 1995Article
- Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.Nucleic acids research · 1995Article
- A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter.Journal of virology · 1995Article
- The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells.Nucleic acids research · 1994Article
- Chromosomal localization of the transcription factor YY1 in the mouse and human.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
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2 authors.
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Abstract
The mouse gene that encodes the delta transcription factor has been cloned and characterized. This gene spans 23 kb and is composed of five exons and four introns. The first exon consists of a long (431 bp), (C+G)-rich, untranslated segment and a 679-bp coding segment, which specifies the unusual tracts of consecutive acidic residues and histidines and the long alanine-glycine stretches. The sequence that encodes the four zinc-finger motifs of this protein is interrupted by two introns. Nuclease protection experiments revealed a major transcriptional start point and several additional start points distributed over a 28-bp segment. Transfection experiments with 5' and 3' deletion mutants localized the promoter to a (C+G)-rich region that is < 700 bp upstream and no more than 32 bp downstream of the major start point. An especially critical promoter element lies between -58 and -18 and contains a high-affinity Sp1 binding site, as demonstrated by electrophoretic mobility-shift experiments with nuclear extract and recombinant Sp1 proteins. Several striking similarities between the delta gene and genes encoding other transcription factors and regulatory proteins are noted and discussed with respect to their possible biological significance.
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