ArticleThe Journal of clinical investigation1993
Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 293 citations in OpenAlex.
- Atherogenesis inCells · 2023Article
- Black soybean seed coat polyphenol ameliorates the abnormal feeding pattern induced by high-fat diet consumption.Frontiers in nutrition · 2022Article
- The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1.Journal of personalized medicine · 2021Review
- Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages.Adipocyte · 2020Article
- Association between a urinary biomarker for exposure to PAH and blood level of the acute phase protein serum amyloid A in coke oven workers.Environmental health : a global access science source · 2019Article
- Iron-Induced Liver Injury: A Critical Reappraisal.International journal of molecular sciences · 2019Review
- Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice.Lipids in health and disease · 2017Article
- New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2017Review
- Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models.International journal of molecular sciences · 2016Review
- Cell adhesion molecules and eNOS expression in aorta of normocholesterolemic mice with different predispositions to atherosclerosis.Heart and vessels · 2015Article
- PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress.Antioxidants & redox signaling · 2014Article
- Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention.Nutrients · 2013Review
- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform.Experimental & molecular medicine · 2013Article
- Hyperglycemia in apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility.Cardiovascular diabetology · 2011Article
- Article
- Genetic effects on postprandial variations of inflammatory markers in healthy individuals.Obesity (Silver Spring, Md.) · 2010Article
- Neurodegenerative diseases: exercising toward neurogenesis and neuroregeneration.Frontiers in aging neuroscience · 2010Article
- HIV-1 antiretrovirals induce oxidant injury and increase intima-media thickness in an atherogenic mouse model.Toxicology letters · 2009Article
- Effect of aging on fatty streak formation in a diet-induced mouse model of atherosclerosis.Journal of vascular research · 2008Article
- Oxidized lipids: the two faces of vascular inflammation.Current atherosclerosis reports · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A high fat, high cholesterol "atherogenic" diet induced considerably greater hepatic levels of conjugated dienes and expression of several inflammatory and oxidative stress responsive genes (JE, the mouse homologue of monocyte chemotactic protein-1, colony-stimulating factors, heme oxygenase, and members of the serum amyloid A family) in fatty streak susceptible C57BL/6 mice compared to fatty streak resistant C3H/HeJ mice. Since serum amyloid A proteins bind exclusively to HDL and influence the properties of HDL, serum amyloid A expression may contribute to the decrease in HDL levels seen in the susceptible strains. Induction of a similar set of genes was observed upon injection of minimally oxidized low density lipoprotein. The transcription factor NF-kappa B is known to be activated by oxidative stress and is involved in the transcriptional regulation of several of these genes. On the atherogenic diet the susceptible C57BL/6 mice exhibited significant NF-kappa B-like activation whereas the resistant C3H/HeJ mice exhibited little or no activation. These results are consistent with the hypothesis that the atherogenic diet resulted in the accumulation of oxidized lipids in certain tissues (e.g., liver and arteries) and the resulting inflammatory response to this oxidative stress was genetically determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.