ArticleGenetics1993
Mutations in POL1 increase the mitotic instability of tandem inverted repeats in Saccharomyces cerevisiae.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability.Nature genetics · 2014Article
- Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae.BMC microbiology · 2013Article
- Genome-wide screen reveals replication pathway for quasi-palindrome fragility dependent on homologous recombination.PLoS genetics · 2013Article
- Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases.Journal of nucleic acids · 2011Article
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- Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.Human molecular genetics · 2009Article
- Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.Genome research · 2009Article
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- Article
- Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair.Microbiology and molecular biology reviews : MMBR · 2002Review
- A 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe.Genetics · 2002Article
- AT-rich palindromes mediate the constitutional t(11;22) translocation.American journal of human genetics · 2001Article
- Inverted Alu repeats unstable in yeast are excluded from the human genome.The EMBO journal · 2000Article
- Long palindromic sequences induce double-strand breaks during meiosis in yeast.Molecular and cellular biology · 2000Article
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- The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Factors affecting inverted repeat stimulation of recombination and deletion in Saccharomyces cerevisiae.Genetics · 1998Article
- Palindrome resolution and recombination in the mammalian germ line.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tandem inverted repeats (TIRs or hairpins) of 30 and 80 base-pair unit lengths are unstable mitotically in yeast (Saccharomyces cerevisiae). TIR instability results from deletions that remove part or all of the presumed hairpin structure from the chromosome. At least one deletion endpoint is always at or near the base of the hairpin, and almost all of the repaired junctions occur within short direct sequence repeats of 4 to 9 base pairs. The frequency of this event, which we call "hairpin excision," is influenced by chromosomal position, length of the inverted repeats, and the distance separating the repeat units; increasing the distance between the inverted repeats as little as 25 base pairs increases their chromosomal stability. The frequency of excision is not affected by representative rad mutations, but is influenced by mutations in certain genes affecting DNA synthesis. In particular, mutations in POL1/CDC17, the gene that encodes the large subunit of DNA polymerase I, increase the frequency of hairpin deletions significantly, implicating this protein in the normal maintainance of genomic TIRs.
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