ArticleAnatomy and embryology1993
The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature.
Article in Anatomy and embryology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 55 citations in OpenAlex.
- Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development.Disease models & mechanisms · 2023Article
- PAX Genes in Cardiovascular Development.International journal of molecular sciences · 2022Review
- Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures.Developmental biology · 2014Article
- Gene regulatory evolution and the origin of macroevolutionary novelties: insights from the neural crest.Genesis (New York, N.Y. : 2000) · 2013Review
- Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor.Glia · 2012Article
- Myogenesis and muscle regeneration.Histochemistry and cell biology · 2012Review
- Functional interaction between Foxd3 and Pax3 in cardiac neural crest development.Genesis (New York, N.Y. : 2000) · 2011Article
- Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease.Pigment cell & melanoma research · 2008Review
- Expression of Connexin 43 in the hearts of rat embryos exposed to nitrofen and effects of vitamin A on it.Pediatric surgery international · 2006Article
- Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.Oncogene · 2000Article
- Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development.The Journal of clinical investigation · 2000Article
- Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors.Science (New York, N.Y.) · 1999Article
- Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.Molecular and cellular biology · 1998Article
- Organization of the spina bifida neural tube in Splotch (Pax-3 defective) mouse embryos.Development, growth & differentiation · 1996Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Homozygous mutants of the murine Splotch (Sp1H) and the Splotch-delayed (Spd) alleles show different phenotypes with respect to neural crest derivatives and their longevity. In this report, Sp1H/Sp1H, Spd/Spd and Sp1H/Spd mouse mutant embryos were examined histologically in serial sections on day 13.5 of gestation. All Spd/Spd and Sp1H/Spd embryos showed a similarly dramatic reduction of the muscle primordia in the limbs that had previously been observed in Sp1H homozygotes. The neural crest-derived spinal ganglia and Schwann cells showed major defects in Sp1H homozygotes and lesser defects in Spd homozygote, with Sp1H/Spd embryos being intermediary. Also, the neural crest-derived septum of the truncus arteriosus was formed in almost none of the Sp1H homozygotes, in roughly half of the Sp1H/Spd double heterozygotes and in all of the Spd homozygotes. Aortic conus malformations were observed in all mutants. The paternal origin of the Sp1H allele in the Sp1H/Spd embryos had no influence on the resulting phenotype. These observations demonstrate that the neural tube defect and the limb muscle defect are the common denominator of both the Splotch and the Splotch-delayed phenotype. The extent of the neural crest defects in the mutant compounds apparently depends on the Splotch alleles involved.
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