Evidence map›Paper›PMID 8510177›Full record

ArticleJournal of molecular evolution1993

Immunoglobulin heavy chain constant and heavy chain variable region genes in phylogenetically diverse species of bony fish.

J C Jones, S H Ghaffari, C J Lobb

Abstract read
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In one paragraph

Article in Journal of molecular evolution, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J C JonesDepartment of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505.
S H Ghaffari
C J Lobb

Funding

SYSTEMIC AND MUCOSAL IMMUNITY IN ECTOTHERMSR01AI023052 · NIAID · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI LOBB, CRAIG J · 1986 to 2000
$199k
NIAID NIH HHS AI-23052
6 · The paper itself

Abstract

Genomic DNA from 18 phylogenetically diverse species of bony fish was hybridized with probes specific for the channel catfish immunoglobulin heavy chain constant (CH) gene, as well as with immunoglobulin heavy chain variable (VH) probes specific for five channel catfish VH gene families. The results showed that CH probes strongly hybridized only to genomic fragments from other catfish species. In contrast, restricted DNA from most other species hybridized with at least two channel catfish VH probes. In those species whose DNA hybridized with multiple VH probes, the restriction pattern of hybridizing fragments was probe-dependent. These studies suggest that (1) the CH gene defined in channel catfish appears to share similarity only with CH genes in other catfish species, (2) families of VH genes appear to have diverged in early phylogenetic lineages of teleosts, and (3) VH genes similar to those defined in catfish appear to be widely represented in phylogenetically diverse species of teleosts.

Indexed as

AnimalsDNA ProbesFishesGenes, ImmunoglobulinGenomeIctaluridaeImmunoglobulin Constant RegionsImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionPhylogenyDNA ProbesImmunoglobulin Constant RegionsImmunoglobulin Heavy ChainsImmunoglobulin Variable Region

Identifiers

PMID8510177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.