ArticleThe Journal of cell biology1993
Cytoskeletal remodeling during growth cone-target interactions.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 246 citations in OpenAlex.
- Abnormal cytoskeletal remodeling but normal neuronal excitability in a mouse model of the recurrent developmental and epileptic encephalopathy-susceptibility KCNB1-p.R312H variant.Communications biology · 2024Article
- Prostaglandin E2 Increases Neurite Length and the Formation of Axonal Loops, and Regulates Cone Turning in Differentiating NE4C Cells Via PKA.Cellular and molecular neurobiology · 2022Article
- The Neuron Navigators: Structure, function, and evolutionary history.Frontiers in molecular neuroscience · 2022Review
- Proteomes, kinases and signalling pathways in virus-induced filopodia, as potential antiviral therapeutics targets.Reviews in medical virology · 2021Review
- Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticityFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering.eLife · 2017Article
- Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation.Molecular biology of the cell · 2017Article
- SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.Molecular neurobiology · 2016Review
- Early-stage development of human induced pluripotent stem cell-derived neurons.Journal of neuroscience research · 2015Article
- Surfing along Filopodia: A Particle Transport Revealed by Molecular-Scale Fluctuation Analyses.Biophysical journal · 2015Article
- Dynamic peripheral traction forces balance stable neurite tension in regenerating Aplysia bag cell neurons.Scientific reports · 2014Article
- Cell biology in neuroscience: RNA-based mechanisms underlying axon guidance.The Journal of cell biology · 2013Review
- Compartmentalized neuronal cultures.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Article
- Forward transport of proteins in the plasma membrane of migrating cerebellar granule cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The function of p120 catenin in filopodial growth and synaptic vesicle clustering in neurons.Molecular biology of the cell · 2012Article
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A pharmacological cocktail for arresting actin dynamics in living cells.Molecular biology of the cell · 2011Article
- The growth cone cytoskeleton in axon outgrowth and guidance.Cold Spring Harbor perspectives in biology · 2011Review
- Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1.Developmental neurobiology · 2010Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reorganization of the cytoskeleton of neuronal growth cones in response to environmental cues underlies the process of axonal guidance. Most previous studies addressing cytoskeletal changes during growth cone pathfinding have focused on the dynamics of a single cytoskeletal component. We report here an investigation of homophilic growth cone-target interactions between Aplysia bag cell neurons using digitally enhanced video microscopy, which addresses dynamic interactions between actin filaments and microtubules. After physical contact of a growth cone with a physiological target, mechanical coupling occurred after a delay; and then the growth cone exerted forces on and displaced the target object. Subsequent to coupling, F-actin accumulation was observed at the target contact zone, followed by preferential microtubule extension to the same site. After successful target interactions, growth cones typically moved off highly adhesive poly-L-lysine substrates into native target cell surfaces. These events were associated with modulation of both the direction and rate of neurite outgrowth: growth cone migration was typically reoriented to a trajectory along the target interaction axis and rates of advance increased by about one order of magnitude. Directed microtubule movements toward the contact site appeared to be F-actin dependent as target site-specific microtubule extension and bundling could be reversibly randomized by micromolar levels of cytochalasin B in a characteristic manner. Our results suggest that target contacts can induce focal F-actin assembly and reorganization which, in turn, guides target site-directed microtubule redistribution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.