ArticleProceedings of the National Academy of Sciences of the United States of America1993
Molecular cloning of olfactomedin, an extracellular matrix protein specific to olfactory neuroepithelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 112 citations in OpenAlex.
- A2-pancortins interact with Bcl-xL and WAVE1 to promote mitochondria-ER contact sites (MERCs) and exacerbate mitochondrial calcium elevation to mediate cell death in stroke.Scientific reports · 2026Article
- Defective Olfactomedin-2 connects adipocyte dysfunction to obesity.Nature communications · 2025Article
- Myocilin misfolding and glaucoma: A 20-year update.Progress in retinal and eye research · 2023Review
- Mutated olfactomedin 1 in the interphotoreceptor matrix of the mouse retina causes functional deficits and vulnerability to light damage.Histochemistry and cell biology · 2017Article
- Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon).Biological research · 2016Article
- Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility.Endocrinology · 2015Article
- Olfactomedin-1 Has a V-shaped Disulfide-linked Tetrameric Structure.The Journal of biological chemistry · 2015Article
- Structural basis for misfolding in myocilin-associated glaucoma.Human molecular genetics · 2015Article
- The olfactomedin domain from gliomedin is a β-propeller with unique structural properties.The Journal of biological chemistry · 2015Article
- The Olfactory Transcriptome and Progression of Sexual Maturation in Homing Chum Salmon Oncorhynchus keta.PloS one · 2015Article
- Quantifying Preferences and Responsiveness of Marine Zooplankton to Changing Environmental Conditions using Microfluidics.PloS one · 2015Article
- Olfactomedin proteins: central players in development and disease.Frontiers in cell and developmental biology · 2014Review
- A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response.Trends in molecular medicine · 2013Review
- OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer.Journal of cancer research and clinical oncology · 2011Article
- Keeping an eye on myocilin: a complex molecule associated with primary open-angle glaucoma susceptibility.Molecules (Basel, Switzerland) · 2011Review
- Systematic characterization of protein-DNA interactions.Cellular and molecular life sciences : CMLS · 2011Review
- Functional role of proteolytic processing of recombinant myocilin in self-aggregation.Investigative ophthalmology & visual science · 2010Article
- Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Molecular neurobiology · 2009Review
- Myocilin is a modulator of Wnt signaling.Molecular and cellular biology · 2009Article
- Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.Investigative ophthalmology & visual science · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The extracellular mucous matrix of olfactory neuroepithelium is a highly organized structure in intimate contact with chemosensory cilia that house the olfactory transduction machinery. Here we describe the molecular cloning and primary structure of olfactomedin, which is the major component of this extracellular matrix. Olfactomedin is expressed exclusively in olfactory neuroepithelium and its amino acid sequence shows no homologies to any known protein. This olfactory tissue-specific glycoprotein contains cysteines which form disulfide-linked polymers that constitute the primary architecture of the olfactory extracellular matrix. By analogy to other extracellular matrix proteins of the nervous system, olfactomedin may influence the maintenance, growth, or differentiation of chemosensory cilia on the apical dendrites of olfactory neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.