ReviewProceedings of the National Academy of Sciences of the United States of America1993
The human genome project.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Review
- Integrated Workflow for Drug Repurposing in Glioblastoma: Computational Prediction and Preclinical Validation of Therapeutic Candidates.Brain sciences · 2025Article
- The misalignment of incentives in academic publishing and implications for journal reform.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification and Analysis of Small Nucleolar RNAs by Real-Time Quantitative PCR.Methods in molecular biology (Clifton, N.J.) · 2025Article
- From DNA to Big Data: NGS Technologies and Their Applications.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Protein sequence analysis in the context of drug repurposing.BMC medical informatics and decision making · 2024Article
- Human pangenome: far-reaching implications in precision medicine.Frontiers of medicine · 2024Article
- A scalable tool for analyzing genomic variants of humans using knowledge graphs and graph machine learning.Frontiers in big data · 2024Article
- Review
- Customized optical mapping by CRISPR-Cas9 mediated DNA labeling with multiple sgRNAs.Nucleic acids research · 2021Article
- Advances in Metagenomics and Its Application in Environmental Microorganisms.Frontiers in microbiology · 2021Review
- Article
- Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- The Adapting Mind in the Genomic Era.Frontiers in psychology · 2016Review
- Genetic anchoring of whole-genome shotgun assemblies.Frontiers in genetics · 2014Review
- A guide to bioinformatics for immunologists.Frontiers in immunology · 2013Review
- Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay.EJIFCC · 2012Article
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.Genome research · 2000Article
- Chromosome-specific molecular organization of maize (Zea mays L.) centromeric regions.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Computational methods for exon detection.Molecular biotechnology · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Human Genome Project in the United States is now well underway. Its programmatic direction was largely set by a National Research Council report issued in 1988. The broad framework supplied by this report has survived almost unchanged despite an upheaval in the technology of genome analysis. This upheaval has primarily affected physical and genetic mapping, the two dominant activities in the present phase of the project. Advances in mapping techniques have allowed good progress toward the specific goals of the project and are also providing strong corollary benefits throughout biomedical research. Actual DNA sequencing of the genomes of the human and model organisms is still at an early stage. There has been little progress in the intrinsic efficiency of DNA-sequence determination. However, refinements in experimental protocols, instrumentation, and project management have made it practical to acquire sequence data on an enlarged scale. It is also increasingly apparent that DNA-sequence data provide a potent means of relating knowledge gained from the study of model organisms to human biology. There is as yet little indication that the infusion of technology from outside biology into the Human Genome Project has been effectively stimulated. Opportunities in this area remain large, posing substantial technical and policy challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.