ArticleNucleic acids research1993
Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 160 citations in OpenAlex.
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- A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.Genome research · 2019Article
- The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism.Cancers · 2019Article
- Targeting RNA in mammalian systems with small molecules.Wiley interdisciplinary reviews. RNA · 2018Review
- Conserved non-coding elements: developmental gene regulation meets genome organization.Nucleic acids research · 2017Review
- CEGA--a catalog of conserved elements from genomic alignments.Nucleic acids research · 2016Article
- Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients.BMC infectious diseases · 2014Article
- Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein.Immunogenetics · 2014Article
- Lineage-specific conserved noncoding sequences of plant genomes: their possible role in nucleosome positioning.Genome biology and evolution · 2014Article
- Heterogeneous tempo and mode of conserved noncoding sequence evolution among four mammalian orders.Genome biology and evolution · 2013Article
- A multispecies polyadenylation site model.BMC bioinformatics · 2013Article
- Versatility of RNA-Binding Proteins in Cancer.Comparative and functional genomics · 2012Article
- Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.The Journal of infectious diseases · 2011Article
- Ultraconserved cDNA segments in the human transcriptome exhibit resistance to folding and implicate function in translation and alternative splicing.Nucleic acids research · 2011Article
- Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs.Nature structural & molecular biology · 2011Article
- Long conserved fragments upstream of Mammalian polyadenylation sites.Genome biology and evolution · 2011Article
- A conserved stem loop motif in the 5'untranslated region regulates transforming growth factor-β(1) translation.PloS one · 2010Article
- A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparison of nucleotide sequences from different classes of vertebrates that diverged more than 300 million years ago, revealed the existence of highly conserved regions (HCRs) with more than 70% similarity over 100 to 1450 nt in non-coding parts of genes. Such a conservation is unexpected because it is much longer and stronger than what is necessary for specifying the binding of a regulatory protein. HCRs are relatively frequent, particularly in genes that are essential to cell life. In multigene families, conserved regions are specific of each isotype and are probably involved in the control of their specific pattern of expression. Studying HCRs distribution within genes showed that functional constraints are generally much stronger in 3'-non-coding regions than in promoters or introns. The 3'-HCRs are particularly A + T-rich and are always located in the transcribed untranslated regions of genes, which suggests that they are involved in post-transcriptional processes. However, current knowledge of mechanisms that regulate mRNA export, localisation, translation, or degradation is not sufficient to explain the strong functional constraints that we have characterised.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.