ArticleGut1993
Intestinal epithelial cells contribute to the enhanced generation of platelet activating factor in ulcerative colitis.
Article in Gut, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium.Mucosal immunology · 2019Article
- Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.Journal of lipid research · 2018Article
- Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators.Pathophysiology : the official journal of the International Society for Pathophysiology · 2014Article
- Concepts of oxidative stress and antioxidant defense in Crohn's disease.World journal of gastroenterology · 2013Review
- Inflammatory signaling in necrotizing enterocolitis.Clinics in perinatology · 2013Review
- Article
- Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.The Biochemical journal · 2006Article
- Key role of mast cells and their major secretory products in inflammatory bowel disease.World journal of gastroenterology · 2004Review
- Differential role of platelet-activating factor in gastric mucosal ulcer healing.Inflammopharmacology · 2003Article
- Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes.Immunology · 2002Article
- Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat.British journal of pharmacology · 2000Article
- Cellular localization of complement C3 and C4 transcripts in intestinal specimens from patients with Crohn's disease.Clinical and experimental immunology · 2000Article
- Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model.Clinical and experimental immunology · 1998Article
- Cyclosporine A inhibits interleukin-8 production in a human colon epithelial cell line (HT-29).Journal of gastroenterology · 1997Article
- Interleukin-8 production by the human colon epithelial cell line HT-29: modulation by interleukin-13.British journal of pharmacology · 1996Article
- Quantification of distinct molecular species of platelet activating factor in ulcerative colitis.Lipids · 1996Article
- Intraluminal excretion of PAF, lysoPAF, and acetylhydrolase in patients with ulcerative colitis.Digestive diseases and sciences · 1995Article
- NO chi generation by cultured small intestinal epithelial cells.Digestive diseases and sciences · 1995Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Generation of platelet activating factor by intestinal mucosal epithelial cells and lamina propria mononuclear cells was evaluated to elucidate the possible role of this mediator in the pathogenesis of inflammatory bowel disease. Epithelial and lamina propria mononuclear cells were isolated from surgical specimens from control, Crohn's disease, and ulcerative colitis patients. Platelet activating factor was extracted from highly purified cell preparations with 80% ethanol after stimulation with and without 0.2 uM calcium ionophore A23187 and was measured by platelet aggregation assay. Both cell types generated platelet activating factor activity and this was generally comparable for epithelial and lamina propria cells. Basal and stimulated platelet activating factor activity of epithelial and lamina propria cells from ulcerative colitis but not Crohn's disease patients was appreciably higher than that of control. Stimulation with calcium ionophore increased appreciably platelet activating factor activity in lamina propria cells from all groups. In contrast, only epithelial cells from ulcerative colitis showed an appreciable increase after calcium ionophore induction. These results suggest that epithelial cells are important contributors to intestinal platelet activating factor generation under normal and inflammatory conditions and that epithelial cells actively play a part in the pathogenesis of ulcerative colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.