ArticleAmerican journal of human genetics1993
A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.
Article in American journal of human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.Molecular psychiatry · 2012Article
- Genomewide association studies: history, rationale, and prospects for psychiatric disorders.The American journal of psychiatry · 2009Review
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.American journal of human genetics · 2005Article
- Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series.Molecular psychiatry · 2003Article
- A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder.Molecular psychiatry · 2003Article
- Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder.Molecular psychiatry · 2002Article
- Genomewide scans of complex human diseases: true linkage is hard to find.American journal of human genetics · 2001Article
- The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia.Molecular psychiatry · 2001Article
- Incorporation of molecular data and redefinition of phenotype: new approaches to genetic epidemiology of bipolar manic depressive illness and schizophrenia.Dialogues in clinical neuroscience · 2001Article
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
- Molecular linkage studies of bipolar disorder.Dialogues in clinical neuroscience · 1999Article
- A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A study of familial aggregation of depression, dementia and Parkinson's disease.European journal of epidemiology · 1998Article
- A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish.American journal of human genetics · 1996Article
- Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.American journal of human genetics · 1995Article
- Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Manic-depressive illness (MDI), also known as "bipolar affective disorder," is a common and devastating neuropsychiatric illness. Although pivotal biochemical alterations underlying the disease are unknown, results of family, twin, and adoption studies consistently implicate genetic transmission in the pathogenesis of MDI. In order to carry out linkage analysis, we ascertained eight moderately sized pedigrees containing multiple cases of the disease. For a four-allele marker mapping 5 cM from the disease gene, the pedigree sample has > 97% power to detect a dominant allele under genetic homogeneity and has > 73% power under 20% heterogeneity. To date, the eight pedigrees have been genotyped with 328 polymorphic DNA loci throughout the genome. When autosomal dominant inheritance was assumed, 273 DNA markers gave lod scores < -2.0 at recombination fraction (theta) = .0, 174 DNA loci produced lod scores < -2.0 at theta = .05, and 4 DNA marker loci yielded lod scores > 1 (chromosome 5--D5S39, D5S43, and D5S62; chromosome 11--D11S85). Of the markers giving lod scores > 1, only D5S62 continued to show evidence for linkage when the affected-pedigree-member method was used. The D5S62 locus maps to distal 5q, a region containing neurotransmitter-receptor genes for dopamine, norepinephrine, glutamate, and gamma-aminobutyric acid. Although additional work in this region may be warranted, our linkage results should be interpreted as preliminary data, as 68 unaffected individuals are not past the age of risk.
Indexed as
Identifiers
8503452PMC1682294W1520180280What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.