ArticleAmerican journal of human genetics1993
Incorrect specification of marker allele frequencies: effects on linkage analysis.
Article in American journal of human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Collapsed haplotype pattern method for linkage analysis of next-generation sequence data.European journal of human genetics : EJHG · 2015Article
- A statistical framework to guide sequencing choices in pedigrees.American journal of human genetics · 2014Article
- Genome-wide analysis of genetic susceptibility to language impairment in an isolated Chilean population.European journal of human genetics : EJHG · 2011Article
- Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms.Molecular psychiatry · 2009Article
- Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3.Journal of human genetics · 2009Article
- Mapping of a new autosomal recessive non-syndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44.Clinical genetics · 2008Article
- Ignoring intermarker linkage disequilibrium induces false-positive evidence of linkage for consanguineous pedigrees when genotype data is missing for any pedigree member.Human heredity · 2008Article
- Ectodermal dysplasia of hair and nail type: mapping of a novel locus to chromosome 17p12-q21.2.The British journal of dermatology · 2006Article
- A novel locus for alopecia with mental retardation syndrome (APMR2) maps to chromosome 3q26.2-q26.31.Clinical genetics · 2006Article
- DFNB68, a novel autosomal recessive non-syndromic hearing impairment locus at chromosomal region 19p13.2.Human genetics · 2006Article
- AUNX1, a novel locus responsible for X linked recessive auditory and peripheral neuropathy, maps to Xq23-27.3.Journal of medical genetics · 2006Article
- Localization of a novel autosomal recessive nonsyndromic hearing impairment locus DFNB65 to chromosome 20q13.2-q13.32.Journal of molecular medicine (Berlin, Germany) · 2006Article
- The mapping of DFNB62, a new locus for autosomal recessive non-syndromic hearing impairment, to chromosome 12p13.2-p11.23.Clinical genetics · 2006Article
- Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment.BMC genetics · 2006Article
- A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3.Human genetics · 2006Article
- Article
- Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB55 to chromosome 4q12-q13.2.Clinical genetics · 2005Article
- A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3.American journal of medical genetics. Part A · 2005Article
- Prospects for admixture mapping of complex traits.American journal of human genetics · 2005Review
- Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis.American journal of human genetics · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most current linkage analyses make use of highly polymorphic DNA markers. Assigning correct allele frequencies for these markers may be extremely difficult in particular study populations. Designation of erroneous frequencies may result in false-positive evidence for linkage, as well as in failure to correctly exclude linkage. These effects are most pronounced in small pedigrees with key individuals unavailable for typing. The power to correctly detect true linkage does not appear to be greatly affected by inaccurate allele frequencies. Before linkage analyses are performed for specific pedigrees, it is recommended that simulation analyses be performed, followed by uncertainty and sensitivity analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.