ArticleInfection and immunity1993
Human submandibular-sublingual saliva promotes adhesion of Candida albicans to polymethylmethacrylate.
Article in Infection and immunity, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 112 citations in OpenAlex.
- Microbial adherence on vacuum-formed retainers with different surface roughness as constructed from conventional stone models and 3D printed models: a randomized controlled clinical trial.Clinical oral investigations · 2023Trial
- Evaluation of Antimicrobials Incorporated into Artificial Saliva: Analysis AgainstJournal of functional biomaterials · 2026Article
- Oil-based saliva substitutes promote Candida albicans biofilm formation in vitro.BMC oral health · 2025Article
- The denture microbiome in health and disease: an exploration of a unique community.Letters in applied microbiology · 2022Review
- Dietary sugars modulate bacterial-fungal interactions in saliva and inter-kingdom biofilm formation on apatitic surface.Frontiers in cellular and infection microbiology · 2022Article
- Influence of the Manufacturing Method on the Adhesion ofPolymers · 2021Article
- Inhibition ofAntibiotics (Basel, Switzerland) · 2021Article
- Article
- The effect of two artificial salivas on the adhesion of Candida albicans to heat-polymerized acrylic resin.The journal of advanced prosthodontics · 2015Article
- An Evaluation of the Adherence of Candida albicans on the Surface of Heat Cure Denture Base Material Subjected to Different Stages of Polishing.Journal of clinical and diagnostic research : JCDR · 2013Article
- New phosphated poly(methyl methacrylate) polymers for the prevention of denture-induced microbial infection: an in vitro study.Clinical, cosmetic and investigational dentistry · 2011Article
- Activity of antimicrobial peptide mimetics in the oral cavity: I. Activity against biofilms of Candida albicans.Molecular oral microbiology · 2010Article
- Conventional and alternative antifungal therapies to oral candidiasis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Adhesive properties and hydrolytic enzymes of oral Candida albicans strains.Mycopathologia · 2010Article
- Candida albicans adhesion to composite resin materials.Clinical oral investigations · 2009Article
- Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine.Archives of oral biology · 2009Article
- The adherence of Candida albicans to acrylic resin reinforced with different fibers.Journal of materials science. Materials in medicine · 2008Article
- Whole Saliva has a Dual Role on the Adherence of Candida albicans to Polymethylmetacrylate.The open dentistry journal · 2008Article
- Adherence of Candida albicans to denture base acrylics and silicone-based resilient liner materials with different surface finishes.Clinical oral investigations · 2007Article
- Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Clinical microbiology reviews · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to identify components of saliva that interact with Candida albicans in solution and that may modulate adhesion to dental acrylic (polymethylmethacrylate [PMMA]) surfaces. Saliva-derived pellicles extracted from C. albicans blastoconidia and hyphal-form cells mixed with fresh human submandibular-sublingual saliva (HSMSL) contained predominantly high- and low-molecular-weight mucins (MG1 and MG2, respectively). In contrast, few components from fresh human parotid saliva were adsorbed to yeast cells. Coating PMMA beads with HSMSL significantly enhanced (10-fold) adhesion of both growth forms of C. albicans compared with human parotid saliva (2-fold), suggesting a role for mucins in adhesion. HSMSL-enhanced adhesion was completely abolished by preadsorbing HSMSL with either blastoconidia or hyphal-form cells prior to coating PMMA. However, coating PMMA with purified salivary mucins or the addition of mucin to preadsorbed saliva did not enhance or restore adhesion to levels found with fresh HSMSL. Adhesion assays employing guanidine-treated fresh HSMSL showed a complete lack of Candida binding, suggesting that subjecting HSMSL to dissociating conditions may alter a property of salivary mucins crucial for C. albicans adhesion. Protease and glycosidase treatment of yeast cells significantly reduced adhesion to HSMSL-coated PMMA. In addition, preincubation of C. albicans with mannose and galactose inhibited adhesion to HSMSL-coated PMMA. These results suggest that mucins may play a role in C. albicans adhesion to saliva-coated PMMA and that a glycoprotein on the yeast surface may be involved in these events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.