ReviewExperientia1993
Proteoglycans of basement membranes.
Review in Experientia, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 162 citations in OpenAlex.
- Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function.Journal of neuroscience research · 2026Review
- Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis.Cellular and molecular life sciences : CMLS · 2022Review
- Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers.Advanced drug delivery reviews · 2016Review
- Metastasis suppressor genes at the interface between the environment and tumor cell growth.International review of cell and molecular biology · 2011Review
- Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization.The Journal of biological chemistry · 2009Article
- Novel interactions of perlecan: unraveling perlecan's role in angiogenesis.Microscopy research and technique · 2008Review
- Article
- Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2002Article
- Systemic administration of TerplexDNA system: pharmacokinetics and gene expression.Pharmaceutical research · 2001Article
- Perlecan maintains the integrity of cartilage and some basement membranes.The Journal of cell biology · 1999Article
- Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins.The EMBO journal · 1999Article
- alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.Molecular biology of the cell · 1999Article
- Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor.Journal of virology · 1998Article
- Agrin can mediate acetylcholine receptor gene expression in muscle by aggregation of muscle-derived neuregulins.The Journal of cell biology · 1998Article
- Quantitative immunohistochemical evidence of a functional gradient of chondroitin 4-sulphate/dermatan sulphate, developmentally regulated in the predentine of rat incisor.The Histochemical journal · 1998Article
- Evidence for the role of proteoglycans in cation-mediated gene transfer.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Proteolytic disruption of laminin-integrin complexes on muscle cells during synapse formation.Molecular and cellular biology · 1996Article
- Structural and functional analysis of the globular domain IVa of the laminin alpha 1 chain and its impact on an adjacent RGD site.The Biochemical journal · 1996Article
- An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix.The Journal of cell biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteoglycans carrying either heparan sulfate and/or chondroitin sulfate side chains are typical constituents of basement membranes. The most prominent proteoglycan (perlecan) consists of a 400-500 kDa core protein and three heparan sulfate chains. Electron microscopy and cDNA sequencing show a complex and elongated domain structure for the core protein which in part is homologous to that of the laminin A chain. This structure may be varied by alternative splicing and proteolysis. Integration into basement membranes probably occurs by heparan sulfate binding to laminin and collagen IV, core protein binding to nidogen and by limited self assembly. The proteoglycan is in addition a cell-adhesive protein which is recognized by beta 1 integrins. Several more proteoglycans with smaller core proteins (10-160 kDa) apparently exist in basement membranes but are less well characterized. Biological functions include control of filtration through basement membranes and binding of growth factors and protease inhibitors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.