ArticleMolecular and cellular biology1993
The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- TYK2 licenses non-canonical inflammasome activation during endotoxemia.Cell death and differentiation · 2021Article
- Innate immune defects in HIV permissive cell lines.Retrovirology · 2016Article
- Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks.Cellular and molecular life sciences : CMLS · 2014Review
- Inteferons pen the JAK-STAT pathway.Seminars in cell & developmental biology · 2008Review
- Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells.Journal of immunology (Baltimore, Md. : 1950) · 2001Article
- Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells.Oncogene · 2000Article
- The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.Molecular and cellular biology · 1999Article
- Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.Molecular and cellular biology · 1996Article
- Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages.Molecular and cellular biology · 1995Article
- Interleukin-3 signals through multiple isoforms of Stat5.The EMBO journal · 1995Article
- Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.Molecular and cellular biology · 1994Article
- Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes.Infection and immunity · 1994Article
- STF-IL-4: a novel IL-4-induced signal transducing factor.The EMBO journal · 1994Article
- A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.Molecular and cellular biology · 1994Article
- Interferon-gamma-activated immature macrophages exhibit a high Trypanosoma cruzi infection rate associated with a low production of both nitric oxide and tumor necrosis factor-alpha.Parasitology research · 1994Article
- Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.The EMBO journal · 1993Article
- Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma interferon activation factor (GAF) rapidly induces transcriptional activation of gamma interferon (IFN-gamma)-responsive genes. Conversion of the GAF from a latent cytoplasmic to an activated, DNA-binding form is an immediate step in the cellular response to IFN-gamma. The amount of IFN-gamma-activated GAF, measured by exonuclease III protection or gel shift assays, increased strongly upon monocytic differentiation of U937 cells. Activated GAF contained the IFN-responsive 91-kDa protein as its DNA-binding activity in gel shift or exonuclease III assays could be inhibited through direct addition of specific antiserum, and it was not present in p91-immunodepleted extracts. There was a differentiation-induced increase in the amount of nonphosphorylated (latent) p91. Transcription rate measurement demonstrated a strong induction of the p91 gene during monocytic differentiation of U937 cells. The amount of p91 which was rapidly phosphorylated in response to IFN-gamma was found to be much higher in the differentiated cells and suggested a differentiation-controlled increase in the signaling leading to p91 phosphorylation. Concomitantly with a better GAF response, transcriptional activation of IFN-gamma-induced genes and the expression of GAF-dependent, transfected reporter plasmids increased in differentiated U937 monocytes. The promonocyte-monocyte transition also affected the IFN-alpha-responsive transcription factor ISGF-3. Differentiated U937 cells contained more of both the alpha-component p91 and the gamma-component p48, which constitutes the DNA-binding subunit of the complex. Our study thus provides evidence that the synthesis of specific transcription factors can be a regulated event to control the cytokine responsiveness of cells during development.
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