ArticleJournal of virology1993
Transforming variants of the avian myc-containing retrovirus FH3 arise prior to phenotypic selection.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Transforming ability of Gag-Myc fusion proteins correlates with Gag-Myc protein stability and transcriptional repression.Oncogene · 2001Article
- Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.Journal of virology · 1999Article
- Development of murine leukemia virus-based self-activating vectors that efficiently delete the selectable drug resistance gene during reverse transcription.Journal of virology · 1999Article
- Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis.Journal of virology · 1998Article
- Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference.Journal of virology · 1997Article
- Detection of evolving viruses.Nature biotechnology · 1996Article
- E- vectors: development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy.Journal of virology · 1995Article
- An internal deletion enhances the transcriptional activity of a recombinant retrovirus in hematopoietic cells in vivo.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The avian retrovirus FH3, which encodes a Gag-Myc fusion protein, transforms chicken macrophages but not fibroblasts. However, passage of FH3 viral stock in fibroblasts leads to emergence of a virus capable of fibroblast transformation. This virus has not acquired myc mutations; instead, it carries internal gag deletions which confer the ability to transform fibroblasts. We now demonstrate that this and similar deletion variants emerge repeatedly during selection. Sequence analysis reveals direct repeats at or near deletion junctions, suggesting that errors during reverse transcription may be involved in genesis of these viruses, which are then positively selected in fibroblast culture. By using the polymerase chain reaction, we found that such variants preexisted in original stocks even before selection, although they could not be detected by focus assay.
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