ArticleJournal of virology1993
Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Viral terminal protein directs early organization of phage DNA replication at the bacterial nucleoid.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.Nucleic acids research · 2007Article
- A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication.Advances in virus research · 2007Review
- Use of synthetic vectors for neutralising antibody resistant delivery of replicating adenovirus DNA.Gene therapy · 2006Article
- Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes.Gene therapy · 2005Article
- Episomal persistence of recombinant adenoviral vector genomes during the cell cycle in vivo.Journal of virology · 2003Article
- Binding of CCAAT displacement protein CDP to adenovirus packaging sequences.Journal of virology · 2003Article
- Functional Implications in Apoptosis by Interferon Inducible Gene Product 1-8D, the Binding Protein to Adenovirus Preterminal Protein.Journal of microbiology (Seoul, Korea) · 2003Article
- Overexpression of the adenovirus type 12 (Ad12) pTP or E1A gene facilitates Ad12 DNA replication in nonpermissive BHK21 hamster cells.Journal of virology · 2001Article
- Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.Gene therapy · 2001Article
- Optimization of the helper-dependent adenovirus system for production and potency in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Nuclear import of moloney murine leukemia virus DNA mediated by adenovirus preterminal protein is not sufficient for efficient retroviral transduction in nondividing cells.Journal of virology · 2000Article
- Construction and preliminary characterization of a library of "lethal" preterminal protein mutant adenoviruses.Journal of virology · 1999Article
- Localization of human cytomegalovirus structural proteins to the nuclear matrix of infected human fibroblasts.Journal of virology · 1998Article
- Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix.Journal of virology · 1998Article
- Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein.Nucleic acids research · 1998Article
- Role of preterminal protein processing in adenovirus replication.Journal of virology · 1997Article
- Domain organization of the adenovirus preterminal protein.Journal of virology · 1997Article
- Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The adenovirus precursor to the terminal protein (pTP), expressed in a vaccinia virus expression system or in native adenovirus, was assayed for its ability to interact with the nuclear matrix. Biochemical function was measured by determining the relative amount of pTP protein or of adenovirus DNA that remained associated with the nuclear matrix after extensive washing. pTP was retained on the matrix whereas beta-galactosidase was not, as assayed by quantitative immunoblot analysis. Nuclear matrix isolated from adenovirus-infected HeLa cells retained bound adenovirus DNA even when washed with 1 M guanidine hydrochloride; this interaction could be inhibited by added purified pTP protein. Analogous experiments with matrix isolated from HeLa cells infected with a recombinant vaccinia virus that expressed pTP showed a similar retention of pTP protein; this association could also be inhibited by added pTP protein. Binding of pTP to nuclear matrix isolated from uninfected cells was saturable, with an apparent Kd of 250 nM and an estimated 2.8 x 10(6) sites for pTP binding per cell nucleus. The association of pTP with matrix is postulated to help direct adenovirus replication complexes to the appropriate locale within the nucleus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.