ArticleThe Journal of experimental medicine1993
Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 168 citations in OpenAlex.
- Multiple Shades of Gray-Macrophages in Acute Allograft Rejection.International journal of molecular sciences · 2023Review
- The innate immune brakes of the lung.Frontiers in immunology · 2023Review
- Macrophages in Organ Transplantation.Frontiers in immunology · 2020Review
- Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity.Trends in immunology · 2019Review
- Location, function, and ontogeny of pulmonary macrophages during the steady state.Pflugers Archiv : European journal of physiology · 2017Review
- Pulmonary Delivery of Virosome-Bound Antigen Enhances Antigen-Specific CD4Frontiers in immunology · 2017Article
- Myeloid Cells in Asthma.Microbiology spectrum · 2017Review
- New insights into the multidimensional concept of macrophage ontogeny, activation and function.Nature immunology · 2016Article
- CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4.BioMed research international · 2015Article
- Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge.Allergy · 2015Article
- Control of regulatory T cells and airway tolerance by lung macrophages and dendritic cells.Annals of the American Thoracic Society · 2014Review
- SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation.Genes and immunity · 2014Article
- Dysregulation of alveolar macrophages unleashes dendritic cell-mediated mechanisms of allergic airway inflammation.Mucosal immunology · 2014Article
- Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.PloS one · 2014Article
- Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance.The Journal of experimental medicine · 2013Article
- Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.Anesthesiology · 2012Article
- Attenuated Bordetella pertussis protects against highly pathogenic influenza A viruses by dampening the cytokine storm.Journal of virology · 2010Article
- Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.The Journal of clinical investigation · 2009Article
- Innate immune control and regulation of influenza virus infections.Journal of leukocyte biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resident pulmonary alveolar macrophages (PAM) play an important role in the maintenance of immunological homeostasis in the lung via downmodulation of local T cell responses in the steady state. The present study demonstrates that this pathway for T cell suppression is reversible via granulocyte/macrophage colony-stimulating factor (GM-CSF). Thus, freshly isolated PAM strongly inhibit mitogen-induced T cell proliferation, and pretreatment of the PAM with cytokine-rich lung-conditioned medium (LCM) generated by exposure of lung to bacterial lipopolysaccharide (LPS) abrogated this suppressive activity. LCM from lungs of normal and athymic nude mice exhibited identical activity. Moreover, the PAM-modulating activity of LCM was inhibited by blocking antibody specific for GM-CSF, and the activity of LCM could be reproduced by recombinant GM-CSF. This suggests that secretion of GM-CSF by mesenchymal cells and/or macrophages under stimulation from agents such as LPS provides a potential mechanism for upregulation of local T cell responsiveness during acute inflammation. In addition, experiments with a range of cytokines indicated that interleukin 4, transforming growth factor beta 1 and tumor necrosis factor alpha (TNF-alpha) exhibited weaker (but significant) modulatory effects on PAM, and (in the case of TNF-alpha) amplified the effects of GM-CSF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.