ArticleImmunology1993
Induction and suppression of cytokine release (tumour necrosis factor-alpha; interleukin-6, interleukin-1 beta) by Escherichia coli pathogenicity factors (adhesions, alpha-haemolysin).
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Bacterial Toxins Are a Never-Ending Source of Surprises: From Natural Born Killers to Negotiators.Toxins · 2021Review
- Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae.Infection and immunity · 2017Article
- Immunomodulation in the canine endometrium by uteropathogenic Escherichia coli.Veterinary research · 2016Article
- The RTX pore-forming toxin α-hemolysin of uropathogenic Escherichia coli: progress and perspectives.Future microbiology · 2013Review
- Lack of a role of cytotoxic necrotizing factor 1 toxin from Escherichia coli in bacterial pathogenicity and host cytokine response in infected germfree piglets.Infection and immunity · 2000Article
- Role of Pseudomonas aeruginosa lipase in inflammatory mediator release from human inflammatory effector cells (platelets, granulocytes, and monocytes.Infection and immunity · 1996Article
- Pore formation by the Escherichia coli alpha-hemolysin: role for mediator release from human inflammatory cells.Infection and immunity · 1994Article
- Effect of growth factors on Escherichia coli alpha-hemolysin-induced mediator release from human inflammatory cells: involvement of the signal transduction pathway.Infection and immunity · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli bacteria expressing mannose-resistant fimbriae/haemagglutination induced the production of substantial amounts of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) from a peripheral human lymphocyte, monocyte, basophil (LMB) cell suspension. In this regard, E. coli bacteria with S-mannose-resistant fimbriae/haemagglutination were the most potent inducers of IL-6 and TNF-alpha secretion, followed by the E. coli strain with P-mannose-resistant fimbriae/haemagglutination. The E. coli alpha-haemolysin did not stimulate cytokine release from human LMB. In fact, this toxin, at non-toxic concentrations, depressed the spontaneous as well as the E. coli-induced production of TNF-alpha, IL-6, IL-1 beta. Our results indicate that two mechanisms may contribute to the severity of E. coli infection: (a) stimulation of cytokine release by type-specific fimbriae/haemagglutination properties and (b) depression of immune response by the E. coli alpha-haemolysin.
Indexed as
Identifiers
8495969PMC1421883W2413151973What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.