ArticleBritish journal of pharmacology1993
Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea-pig taenia caeci.
Article in British journal of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- CPI-17-deficient smooth muscle of chicken.The Journal of physiology · 2004Article
- Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension.British journal of pharmacology · 2003Article
- Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles.Journal of muscle research and cell motility · 2001Article
- The mechanism of the decrease in cytosolic Ca2+ concentrations induced by angiotensin II in the high K(+)-depolarized rabbit femoral artery.British journal of pharmacology · 2000Article
- Inhibition of muscarinic receptor-induced inositol phospholipid hydrolysis by caffeine, beta-adrenoceptors and protein kinase C in intestinal smooth muscle.British journal of pharmacology · 1995Article
- Sensitization of the contractile system of canine colonic smooth muscle by agonists and phorbol ester.The Journal of physiology · 1994Article
- Influence of phorbol esters on contractile force, action potential and calcium current of isolated guinea-pig heart tissues.Basic research in cardiologyArticle
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Effects of phorbol esters on the cytosolic Ca2+ level ([Ca2+]i) and muscle tension in the intestinal smooth muscle of guinea-pig taenia caeci were examined. 2. 12-Deoxyphorbol 13-isobutyrate (DPB, 1 microM) did not change the [Ca2+]i and tension in resting muscle. 3. In high K(+)-stimulated muscle, 1 microM DPB transiently augmented the contraction and decreased [Ca2+]i. 12-Deoxyphorbol 13-isobutyrate 20-acetate (1 microM) and phorbol 12, 13-dibutyrate (1 microM) showed similar effects to DPB whereas phorbol 12-myristate 13-acetate (1 microM) and phorbol 12, 13-didecanoate (1 microM) were ineffective. 4. DPB (1 microM) inhibited both [Ca2+]i and tension stimulated by 300 nM carbachol or 3 microM histamine. In the presence of a higher concentration of carbachol (1 microM), DPB decreased [Ca2+]i and transiently increased muscle tension. 5. In the muscle strips permeabilized with bacterial alpha-toxin, 1 microM DPB shifted the Ca(2+)-tension curve to the left. An inhibitor of protein kinase C, H-7 (30 microM), inhibited the effect of DPB. 6. DPB did not change the high K(+)-induced contraction in the muscle strips pretreated with 3 microM phorbol 12-myristate 13-acetate for 24 h. 7. These results suggest that activation of protein kinase C has dual effects; it augments contraction by increasing the Ca2+ sensitivity of the contractile elements and it inhibits contraction by decreasing [Ca2+]i.
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