ArticleBiophysical journal1993
New physical concepts for cell amoeboid motion.
Article in Biophysical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Mathematics of cell motility: have we got its number?Journal of mathematical biology · 2009Review
- Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Traveling wave solutions for a one-dimensional crawling nematode sperm cell model.Journal of mathematical biology · 2004Article
- Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The relationship between force and focal complex development.The Journal of cell biology · 2002Article
- An elastic analysis of Listeria monocytogenes propulsion.Biophysical journal · 2000Article
- Keratocytes pull with similar forces on their dorsal and ventral surfaces.The Journal of cell biology · 1999Article
- Myosin I contributes to the generation of resting cortical tension.Biophysical journal · 1999Article
- Cell motility driven by actin polymerization.Biophysical journal · 1996Article
- Imaging the traction stresses exerted by locomoting cells with the elastic substratum method.Biophysical journal · 1996Article
- Stochastic model of receptor-mediated cytomechanics and dynamic morphology of leukocytes.Journal of mathematical biology · 1996Article
- Mechanically stimulated cytoskeleton rearrangement and cortical contraction in human neutrophils.Biophysical journal · 1995Article
- Cell-substrate interactions and locomotion of Dictyostelium wild-type and mutants defective in three cytoskeletal proteins: a study using quantitative reflection interference contrast microscopy.Biophysical journal · 1995Article
- Traction forces generated by locomoting keratocytes.The Journal of cell biology · 1994Article
- Granula motion and membrane spreading during activation of human platelets imaged by atomic force microscopy.Biophysical journal · 1994Article
- Synchrony of cell spreading and contraction force as phagocytes engulf large pathogens.The Journal of cell biology · 1993Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Amoeboid motion of cells is an essential mechanism in the function of many biological organisms (e.g., the regiment of scavenger cells in the immune defense system of animals). This process involves rapid chemical polymerization (with numerous protein constituents) to create a musclelike contractile network that advances the cell over the surface. Significant progress has been made in the biology and biochemistry of motile cells, but the physical dynamics of cell spreading and contraction are not well understood. The reason is that general approaches are formulated from complex mass, momentum, and chemical reaction equations for multiphase-multicomponent flow with the nontrivial difficulty of moving boundaries. However, there are strong clues to the dynamics that allow bold steps to be taken in simplifying the physics of motion. First, amoeboid cells often exhibit exceptional kinematics, i.e., steady advance and retraction of local fixed-shape patterns. Second, recent evidence has shown that cell projections "grow" by polymerization along the advancing boundary of the cell. Together, these characteristics represent a local growth process pinned to the interfacial contour of a contractile network. As such, the moving boundary becomes tractable, but subtle features of the motion lead to specific requirements for the chemical nature of the boundary polymerization process. To demonstrate these features, simple examples for limiting conditions of substrate interaction (i.e., "strong" and "weak" adhesion) are compared with data from experimental studies of yeast particle engulfment by blood granulocytes and actin network dynamics in fishscale keratocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.