ArticleThe Journal of cell biology1993
Control of lens epithelial cell survival.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- The Role of Chloride Channels in the Multidrug Resistance.Membranes · 2021Review
- Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts.Investigative ophthalmology & visual science · 2021Article
- Treatment with retinoic acid and lens epithelial cell-conditioned mediumExperimental and therapeutic medicine · 2015Article
- Article
- Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.PloS one · 2014Article
- Growth of the eye lens: I. Weight accumulation in multiple species.Molecular vision · 2014Article
- Article
- Primary cultures of embryonic chick lens cells as a model system to study lens gap junctions and fiber cell differentiation.The Journal of membrane biology · 2012Review
- CD44-positive cells are candidates for astrocyte precursor cells in developing mouse cerebellum.Cerebellum (London, England) · 2012Article
- Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro.PloS one · 2012Article
- Development and use of the lens epithelial explant system to study lens differentiation and cataractogenesis.Progress in retinal and eye research · 2010Review
- Essential role of BMPs in FGF-induced secondary lens fiber differentiation.Developmental biology · 2008Article
- Nitric oxide, a survival factor for lens epithelial cells.Molecular vision · 2008Article
- FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability.Molecular biology of the cell · 2007Article
- Lens stem cells may reside outside the lens capsule: an hypothesis.Theoretical biology & medical modelling · 2007Article
- A hierarchy of proliferative cells exists in mouse lens epithelium: implications for lens maintenance.Investigative ophthalmology & visual science · 2006Article
- Cellular distribution of lens epithelium-derived growth factor (LEDGF) in the rat eye: loss of LEDGF from nuclei of differentiating cells.Histochemistry and cell biology · 2003Article
- Developmental aspects of galectin-3 expression in the lens.Histochemistry and cell biology · 2003Article
- Programmed cell death in cell cultures.Plant molecular biology · 2000Review
- Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the survival requirements of developing lens epithelial cells to test the hypothesis that most cells are programmed to kill themselves unless they are continuously signaled by other cells not to do so. The lens cells survived for weeks in both explant cultures and high-density dissociated cell cultures in the absence of other cells or added serum or protein, suggesting that they do not require signals from other cell types to survive. When cultured at low density, however, they died by apoptosis, suggesting that they depend on other lens epithelial cells for their survival. Lens epithelial cells cultured at high density in agarose gels also survived for weeks, even though they were not in direct contact with one another, suggesting that they can promote one another's survival in the absence of cell-cell contact. Conditioned medium from high density cultures promoted the survival of cells cultured at low density, suggesting that lens epithelial cells support one another's survival by secreting survival factors. We show for the first time that normal cell death occurs within the anterior epithelium in the mature lens, but this death is strictly confined to the region of the anterior suture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.