ArticleGut1993
Rectal epithelial cell proliferation patterns as predictors of adenomatous colorectal polyp recurrence.
Article in Gut, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Effects of calcium and vitamin D3 on transforming growth factors in rectal mucosa of sporadic colorectal adenoma patients: a randomized controlled trial.Molecular carcinogenesis · 2015Trial
- Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk.Gastroenterology · 2008Trial
- Trial
- The effect of calcium supplements on rectal mucosal proliferation.British journal of cancer · 1995Trial
- Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and WNT-pathway-related markers of bowel cancer risk.The British journal of nutrition · 2019Article
- Correlating colorectal cancer risk with field carcinogenesis progression using partial wave spectroscopic microscopy.Cancer medicine · 2018Article
- The genetics and molecular biology of colonic neoplasia: practical implications for the clinician.Current opinion in gastroenterology · 2017Review
- In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa.Pancreas · 2015Article
- Field cancerisation in colorectal cancer: a new frontier or pastures past?World journal of gastroenterology · 2015Review
- Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.Journal of biomedical optics · 2014Article
- Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells.International journal of cancer · 2013Article
- Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification.Journal of Cancer · 2013Article
- Article
- Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.Cancer research · 2012Article
- Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.Cancer letters · 2011Article
- Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening.Gastroenterology · 2011Article
- Identification of the Eph receptor pathway as a novel target for eicosapentaenoic acid (EPA) modification of gene expression in human colon adenocarcinoma cells (HT-29).Nutrition & metabolism · 2010Article
- Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy.Cancer research · 2009Article
- Association between rectal optical signatures and colonic neoplasia: potential applications for screening.Cancer research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether proliferative patterns in flat rectal mucosal samples can predict the recurrence of adenomatous colorectal polyps, after polypectomy, biopsy specimens from normal looking rectal mucosa were obtained at endoscopy from 55 patients diagnosed for the first time as having adenomatous colorectal polyps. Epithelial cell proliferation was assessed in biopsy specimens through 3H-thymidine autoradiography. After polypectomy, patients were followed for 24 months and underwent complete colonoscopy every 6 months to detect and remove any metachronous lesions. In 40 patients second biopsy specimens were taken during one of the follow up colonoscopies to evaluate the stability of proliferative indices over time. The ratio of labelled (S phase) to total cells (labelling index) for the entire crypt, as well as ratios for each of the five equal compartments into which the crypt had been divided longitudinally, was calculated for each patient. Mean labelling indices for upper crypt compartments 3 and 4 + 5 in the 22 patients in whom polyps recurred were significantly higher (respectively p < 0.05 and p < 0.01) than those of the 33 without recurrence suggesting that an upward shift of the crypt's replicative compartment is associated with polyp recurrence. Labelling indices remained essentially unchanged in those patients who underwent biopsy twice. Reproducible kinetic parameters such as these might be useful in planning follow up of patients with adenomatous polyps after polypectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.