Evidence map›Paper›PMID 8491194›Full record

ArticleThe EMBO journal1993

The Aspergillus nidulans yA gene is regulated by abaA.

R Aramayo, W E Timberlake

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Potential Antifungal Targets forInternational journal of molecular sciences · 2022
    Review
  3. Review
  4. Article
  5. The putative CJournal of microbiology (Seoul, Korea) · 2020
    Article
  6. Influence of iron and copper on the activity of laccases in Fusarium oxysporum f. sp. lycopersici.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2018
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Molecular regulation of beta-lactam biosynthesis in filamentous fungi.Microbiology and molecular biology reviews : MMBR · 1998
    Review
  20. Asexual sporulation in Aspergillus nidulans.Microbiology and molecular biology reviews : MMBR · 1998
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R AramayoDepartment of Genetics, University of Georgia, Athens 30602.
W E Timberlake
University of Georgia · US

Funding

NIGMS NIH HHS GM 37886
6 · The paper itself

Abstract

The developmentally regulated Aspergillus nidulans yA gene encodes a p-diphenol oxidase that is needed for synthesis of green conidial pigment. We subjected the yA 5' flanking region to mutational analysis in A. nidulans and Saccharomyces cerevisiae to identify DNA sequence elements involved in its transcriptional control, and identified two functionally distinct elements. Element I contained potential BrlA binding sites and was required for full level yA transcription, but not for developmental regulation in the presence of element II. Element II contained putative TEF-1 binding sites flanking a CCAAT element and was sufficient for developmental regulation of transcription. Mutation of the TEF-1 binding sites eliminated developmental regulation, whereas mutation of the CCAAT element led to elevated levels of transcription. Element II was also sufficient to induce transcription in S. cerevisiae when the A.nidulans developmental regulatory gene abaA was expressed from the GAL1 promoter. As AbaA and TEF-1 possess similar DNA binding domains, the abaA-yA interaction in yeast is probably direct. Thus, abaA appears to be a direct activator of yA, but yA regulation may also involve interactions with BrlA and a member of the CCAAT class of DNA binding proteins.

Indexed as

Gene Expression Regulation, FungalGenes, RegulatorNuclear ProteinsAmino Acid SequenceAspergillus nidulansBase SequenceBinding SitesCatechol OxidaseDNA-Binding ProteinsDNA, FungalDNA Mutational AnalysisGenes, FungalMolecular Sequence DataPromoter Regions, GeneticSaccharomyces cerevisiaeSequence DeletionCatechol OxidaseDNA-Binding ProteinsDNA, FungalNuclear ProteinsTEAD1 protein, humanTEA Domain Transcription FactorsTranscription Factors

Identifiers

PMID8491194
PMCPMC413426
OpenAlexW183682957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.