ArticleThe Biochemical journal1993
A novel N-terminal motif for palmitoylation of G-protein alpha subunits.
Article in The Biochemical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 160 citations in OpenAlex.
- Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition.Nature communications · 2025Article
- Recruitment, regulation, and release: Control of signaling enzyme localization and function by reversible S-acylation.The Journal of biological chemistry · 2024Review
- Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo.Nature communications · 2022Article
- Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target.Frontiers in molecular neuroscience · 2019Review
- GPCR Modulation in Breast Cancer.International journal of molecular sciences · 2018Review
- Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods.Scientific reports · 2017Article
- Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis.Biomolecules & therapeutics · 2017Review
- Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems.Scientific reports · 2016Article
- Functional compartmentalization of the plasma membrane of neurons by a unique acyl chain composition of phospholipids.The Journal of biological chemistry · 2014Article
- Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex.The Journal of biological chemistry · 2014Article
- Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling.The Journal of biological chemistry · 2011Article
- Exploring protein lipidation with chemical biology.Chemical reviews · 2011Review
- The intracellular dynamic of protein palmitoylation.The Journal of cell biology · 2010Review
- N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).Cellular signalling · 2008Article
- Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting.The Biochemical journal · 2001Article
- Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains.The Biochemical journal · 2001Article
- Effects of prenatal exposure to cocaine on the developing brain: anatomical, chemical, physiological and behavioral consequences.Neurotoxicity research · 2001Article
- Functional roles for fatty acylated amino-terminal domains in subcellular localization.Molecular biology of the cell · 1999Article
- 1,4-benzoquinone reductase from Phanerochaete chrysosporium: cDNA cloning and regulation of expression.Applied and environmental microbiology · 1999Article
- Persistent membrane association of activated and depalmitoylated G protein alpha subunits.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the post-translational processing of G alpha subunits expressed endogenously in rat PC12 and NG108-15 rat/mouse hybrid cells, and after transfection of cDNA expression constructs into COS cells. Thioester-linked palmitoylation of alpha o, alpha s, alpha q/alpha 11 and alpha 12 has been detected by metabolic labelling with [3H]palmitate and immunoprecipitation. Palmitoylation of alpha o occurs post-translationally in cells treated with protein-synthesis inhibitors, suggesting possible dynamic acylation. Palmitoylation of the C-terminal CAAX motif has been excluded. Site-directed mutagenesis of alpha o has been used to implicate the site of modification as a cysteine residue next to the N-terminal myristoylated glycine, in a novel protein-lipid modification motif Met-Gly-Cys. The non-palmitoylated alpha o mutant is still myristoylated but shows reduced membrane binding, suggesting that reversible palmitoylation may regulate G alpha localization and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.