ArticleProceedings of the National Academy of Sciences of the United States of America1993
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 135 citations in OpenAlex.
- The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.Journal of leukocyte biology · 2012Trial
- Article
- Signaling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin.Journal of innate immunity · 2012Article
- Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.Journal of virology · 2011Article
- Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction.The Journal of experimental medicine · 2001Article
- Signal-transduction defects in T cells.Clinical reviews in allergy & immunology · 2001Review
- Review
- A human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling.The Journal of clinical investigation · 2000Article
- Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.Microbiology and molecular biology reviews : MMBR · 1999Review
- Recent advances in the understanding of interleukin-2 signal transduction.Journal of clinical immunology · 1998Review
- Protein kinase C in IL-2 signal transduction.Immunologic research · 1997Review
- Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor.The Journal of cell biology · 1996Article
- Involvement of tyrosine kinases in the induction of cyclo-oxygenase-2 in human endothelial cells.The Biochemical journal · 1995Article
- Human intestinal epithelial cells express functional cytokine receptors sharing the common gamma c chain of the interleukin 2 receptor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.Molecular and cellular biology · 1995Article
- Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.The EMBO journal · 1995Article
- Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.The Journal of cell biology · 1995Article
- Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.Journal of virology · 1995Article
- Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.The Biochemical journal · 1995Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The binding of interleukin 2 (IL-2) to the IL-2 receptor (IL-2R) induces a rapid increase in tyrosine phosphorylation of cellular proteins. In a previous study, we have shown that p56lck (lck), a src-family protein tyrosine kinase (src-PTK), physically and functionally associates with the IL-2R beta chain (IL-2R beta). To further investigate a role of src-PTKs in IL-2 signaling, we analyzed a mouse pro-B-cell line, in which lck is not expressed detectably. We observed that in this cell line, IL-2 induces activation of at least two src-PTKs, p59fyn (fyn) and p53/56lyn (lyn). Interestingly, stimulation of this cell line with IL-3 also induces activation of src-PTKs. The activation of fyn or lyn seems to be selective for stimulation with IL-2 or IL-3 since stimulation with IL-6 fails to activate them. Furthermore, we provide evidence for the physical association of fyn with IL-2R beta. Taken together with previous results, our current study suggests that different src-PTKs, each of which is expressed in a cell-type-specific manner, can participate in the IL-2 signal transduction.
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