ArticleInternational archives of occupational and environmental health1993
Salivary cortisol for monitoring circadian rhythm variation in adrenal activity during shiftwork.
Article in International archives of occupational and environmental health, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis function.Psychoneuroendocrinology · 2006Trial
- Article
- Relationship between circadian rhythm and brain cognitive functions.Frontiers of optoelectronics · 2021Review
- Network between Cytokines, Cortisol and Occupational Stress in Gas and Oilfield Workers.International journal of molecular sciences · 2020Article
- Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity.Scientific reports · 2016Article
- Neuroendocrine recovery after 2-week 12-h day and night shifts: an 11-day follow-up.International archives of occupational and environmental health · 2015Article
- Relationship between vagal tone, cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the validity of salivary cortisol for monitoring circadian rhythm variation in adrenal activity during shiftwork, saliva and blood samples were collected at 4-h intervals in experimental short-term shifts, i.e., day (work 0830-1600 h; sleep 0030-0800 h), evening (work 1630-2400 h; sleep 0430-1200 h), and night (work 0030-0800 h; sleep 1230-2000 h) shifts over 2 days. Cortisol levels, determined by radioimmunoassay, and the circadian profiles of saliva and sera were compared. The salivary cortisol showed relatively low levels, the 2-day mean value being 3.1%-3.3% that of serum total cortisol through all shifts. Significant differences in the serum to saliva cortisol ratios were noted among shifts and subjects. When expressed as a relative percentage of a 2-day mean value, however, salivary cortisol paralleled the modified circadian profiles of serum total cortisol of the evening and night shifts, with no significant time lag and no difference in magnitude. The cosinor analysis supported this finding. Thus, salivary cortisol appears to be an excellent measure for monitoring circadian rhythm variation in adrenal activity in healthy individuals during shiftwork.
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Registered trials
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