ArticleImmunogenetics1993
Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection.
Article in Immunogenetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Experimental structures of antibody/MHC-I complexes reveal details of epitopes overlooked by computational prediction.bioRxiv : the preprint server for biology · 2023Article
- Minimal Information about MHC Multimers (MIAMM).Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Murine MHC class Ib gene, H2-M2, encodes a conserved surface-expressed glycoprotein.Immunogenetics · 2004Article
- Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand.The Journal of experimental medicine · 2001Article
- Characterization of a recent retroposon insertion on mouse chromosome 2 and localization of the cognate parental gene to chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Unexpected beta2-microglobulin sequence diversity in individual rainbow trout.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Sequence divergence of B2m in different cattle populations.Immunogenetics · 1995Article
- Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.The Journal of experimental medicine · 1994Article
- Assembly-dependent expression of antigenic epitopes by beta 2-microglobulin(b).Immunogenetics · 1993Article
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Authors and funding
4 authors.
Funding
Abstract
Mouse beta 2-microglobulin (beta 2m) is polymorphic. Sequences of five allelic wild mouse B2m genes have been determined from the large exons of genomic DNA using the polymerase chain reaction. Relative to the standard B2m(a) allele, the products of four alleles of Mus musculus origin (w2, w3, w4, and w5), differ by only one or two amino acids. w5 has a single nucleotide change, Asp85-->Val, and is identical to the c allele. w3 has two changes, Val(-13)-->Ile and Lys44-->Glu. w2 differs at Arg81-->Thr and w4 at His34-->Gln, and they share the Asp85-->Val change with B2mc and B2mw5. w5 and c cells are lysed by S19.8, a monoclonal antibody specific for beta 2mb (Ala85), in a complement-mediated cytotoxicity assay, whereas w4 cells are not. Thus, distant changes appear to introduce subtle conformational effects on beta 2m structure. Five independent isolates of Mus spretus (w1) differ the most from B2m(a), with 12 amino acid changes and only one silent substitution. Replacements predicted from the nucleotide sequence occur in loops of the molecule facing away from the class I heavy chain and not in regions where beta 2m associates with class I alpha 3 domains. Concordantly, the w1-5 allelic forms of beta 2m associate well with H-2 heavy chains. The many amino acid changes in the spretus sequence and the paucity of silent substitutions suggest that B2m has been subject to positive selection.
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