ArticleCalcified tissue international1993
Effect of 24R,25-dihydroxyvitamin D3 on the formation and function of osteoclastic cells.
Article in Calcified tissue international, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 34 citations in OpenAlex.
- Cellular and molecular effects of thiazolidinediones on bone cells: a review.International journal of biochemistry and molecular biology · 2011Article
- Tissue specific expression and differential regulation by 1alpha,25-dihydroxyvitamin D3 of the calcium-sensing receptor (CaSR) gene in rat kidney, intestine, and calvaria.Cytotechnology · 2001Article
- Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium.Occupational and environmental medicine · 1998Article
- Inhibition of development of N,N'-dimethylhydrazine-induced rat colonic aberrant crypt foci by pre, post and simultaneous treatments with 24R,25-dihydroxyvitamin D3.Japanese journal of cancer research : Gann · 1997Article
- Development of a new method for obtaining osteoclasts from endosteal surfaces.In vitro cellular & developmental biology. Animal · 1996Article
- Vitamin D3 analogs and salmon calcitonin partially reverse the development of renal osteodystrophy in rats.Calcified tissue international · 1995Article
- Effects of vitamin D metabolites on axolotl limb regeneration.Development, growth & differentiation · 1995Article
- Calcium regulating activity of 26,27-dimethyl analog of 24R,25-dihydroxyvitamin D3.Calcified tissue international · 1994Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous reports demonstrated that the administration of large doses of 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] to animals with normal vitamin D supply causes an increase in bone volume with reduced bone resorption and decreased osteoclast number. The present study was undertaken to clarify if 24R,25(OH)2D3 has any inhibitor effect on the formation and function of osteoclasts. The effect of 24R,25(OH)2D3 on the formation of osteoclastic cells was examined by measuring the number of tartrate-resistant acid phosphatase-positive multinucleated cells (MNCs) formed from hemopoietic progenitor cells obtained from spleens of 5-fluorouracil-treated mice. Treatment with 1,25(OH)2D3 or parathyroid hormone fragment 1-34 [PTH(1-34)] stimulated osteoclast-like MNC formation in a dose-dependent manner. Addition of 24R,25(OH)2D3 alone showed a weak stimulatory effect on MNC formation at 10(-6) M, which appeared to be due to its binding to 1,25(OH)2D3 receptors. In contrast, when 24R,25(OH)2D3 was added together with 1,25(OH)2D3 or PTH(1-34), it inhibited osteoclast-like MNC formation stimulated by these hormones. A significant inhibition of MNC formation was observed with 10(-7) M 24R,25(OH)2D3, and the stimulatory effect of 1,25(OH)2D3 or PTH(1-34) was almost completely eliminated with 10(-6) M 24R,25(OH)2D3. Neither 24S,25(OH)2D3 nor 25(OH)D3 exhibited a similar inhibitory effect. The effect of 24R,25(OH)2D3 on the resorptive function of osteoclasts was examined by measuring the formation of resorption pits by mouse bone cells on dentine slices. Treatment with 24R,25(OH)2D3 also inhibited the resorption pit formation stimulated by 1,25(OH)2D3 or PTH(1-34) with similar dose response.(ABSTRACT TRUNCATED AT 250 WORDS)
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