ArticleNucleic acids research1993
Different TRE-related elements are distinguished by sets of DNA-binding proteins with overlapping sequence specificity.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.The Biochemical journal · 2002Article
- Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.Genes & development · 2001Article
- Epidermal growth factor induction of the c-jun promoter by a Rac pathway.Molecular and cellular biology · 1998Article
- Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes.The Biochemical journal · 1997Article
- The DNA binding domains of the yeast Gal4 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs.Nucleic acids research · 1995Article
- Transcriptional control of human papillomavirus (HPV) oncogene expression: composition of the HPV type 18 upstream regulatory region.Journal of virology · 1993Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several promoter elements with sequence similarity to the prototype TPA-responsive element (TRE) were compared by mobility-shift analyses. Activities within whole cell extracts were identified that bind to the TRE-like elements in the collagenase, the somatostatin, and the c-jun promoters. The corresponding factors appeared to differ in their degree of selectivity for these TRE-like sequences. One protein species bound equally well to all TREs. In addition, a subset of specific activities recognised only the somatostatin and the c-jun-derived element and one DNA-protein complex had exclusive specificity for the TRE present in the c-jun promoter. By antibody 'supershift' assays some of the protein components of the specific complexes were identified as CREB- and ATF-related products. Based on these data we postulate that bZip protein dimers differ in their ability to tolerate variations from the canonical TRE sequence. We propose that TRE-like promoter elements are distinguished by this ability to bind to different subsets of a family of related transcription factors.
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