ArticleJournal of bacteriology1993
The frequency and accuracy of replication past a thymine-thymine cyclobutane dimer are very different in Saccharomyces cerevisiae and Escherichia coli.
Article in Journal of bacteriology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Distinct requirements for budding yeast Rev1 and Polη in translesion DNA synthesis across different types of DNA damage.Current genetics · 2020Article
- Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.Mutation research · 2010Article
- Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.Chemical research in toxicology · 2010Article
- Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.DNA repair · 2008Article
- Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions.Molecular and cellular biology · 2006Article
- Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain.Molecular and cellular biology · 2005Article
- Article
- The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.Nucleic acids research · 2005Article
- Role of DNA polymerase eta in the bypass of abasic sites in yeast cells.Nucleic acids research · 2004Article
- Enzymatic switching for efficient and accurate translesion DNA replication.Nucleic acids research · 2004Article
- The Dewar photoproduct of thymidylyl(3'-->5')- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the "A rule".Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Intrinsic polymerase activities of UmuD'(2)C and MucA'(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer.Journal of bacteriology · 2000Article
- Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Solution structure of a DNA decamer duplex containing the stable 3' T.G base pair of the pyrimidine(6-4)pyrimidone photoproduct [(6-4) adduct]: implications for the highly specific 3' T --> C transition of the (6-4) adduct.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Thermodynamic and base-pairing studies of matched and mismatched DNA dodecamer duplexes containing cis-syn, (6-4) and Dewar photoproducts of TT.Nucleic acids research · 1998Article
- Analysis of damage tolerance pathways in Saccharomyces cerevisiae: a requirement for Rev3 DNA polymerase in translesion synthesis.Molecular and cellular biology · 1998Article
- Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.Nucleic acids research · 1996Article
- The T-T pyrimidine (6-4) pyrimidinone UV photoproduct is much less mutagenic in yeast than in Escherichia coli.Nucleic acids research · 1995Article
- Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- U-U and T-T cyclobutane dimers have different mutational properties.Nucleic acids research · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have compared the mutagenic properties of a T-T cyclobutane dimer in baker's yeast, Saccharomyces cerevisiae, with those in Escherichia coli by transforming each of these species with the same single-stranded shuttle vector carrying either the cis-syn or the trans-syn isomer of this UV photoproduct at a unique site. The mutagenic properties investigated were the frequency of replicational bypass of the photoproduct, the error rate of bypass, and the mutation spectrum. In SOS-induced E. coli, the cis-syn dimer was bypassed in approximately 16% of the vector molecules, and 7.6% of the bypass products had targeted mutations. In S. cerevisiae, however, bypass occurred in about 80% of these molecules, and the bypass was at least 19-fold more accurate (approximately 0.4% targeted mutations). Each of these yeast mutations was a single unique event, and none were like those in E. coli, suggesting that in fact the difference in error rate is much greater. Bypass of the trans-syn dimer occurred in about 17% of the vector molecules in both species, but with this isomer the error rate was higher in S. cerevisiae (21 to 36% targeted mutations) than in E. coli (13%). However, the spectra of mutations induced by the latter photoproduct were virtually identical in the two organisms. We conclude that bypass and error frequencies are determined both by the structure of the photoproduct-containing template and by the particular replication proteins concerned but that the types of mutations induced depend predominantly on the structure of the template. Unlike E. coli, bypass in S. cerevisiae did not require UV-induced functions.
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