ArticleThe American journal of pathology1993
Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- A Comparison of Clinical Outcomes between Endoscopic Resection and Surgical Resection in Ampullary Tumors.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Chromosome 5 allelic losses are early events in tumours of the papilla of Vater and occur at sites similar to those of gastric cancer.British journal of cancer · 1998Trial
- Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.Virchows Archiv : an international journal of pathology · 1994Trial
- Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study.World journal of gastroenterology · 2022Article
- Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis.BMC gastroenterology · 2021Article
- Endoscopic Papillectomy for Ampullary Adenomas: Different Outcomes in Sporadic Tumors and Those Associated with Familial Adenomatous Polyposis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Endoscopic Resection of Ampullary Tumours: Long-term Outcomes and Adverse Events.Journal of the Canadian Association of Gastroenterology · 2020Article
- Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Endoscopic resection of advanced ampullary adenomas: a single-center 14-year retrospective cohort study.Surgical endoscopy · 2019Article
- Clinical Impact of Piecemeal Resection Concerning the Lateral Spread of Ampullary Adenomas.Internal medicine (Tokyo, Japan) · 2019Article
- Surgical method choice and coincidence rate of pathological diagnoses in transduodenal ampullectomy: A retrospective case series study and review of the literature.World journal of clinical cases · 2019Article
- Molecular Aberrations in Periampullary Carcinoma.Indian journal of surgical oncology · 2017Article
- Therapeutic outcomes of endoscopic papillectomy for ampullary neoplasms: retrospective analysis of a multicenter study.BMC gastroenterology · 2017Article
- The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy.Archives of pathology & laboratory medicine · 2013Article
- Minor Papilla Adenoma Management in Patients with Pancreas Divisum and Familial Adenomatous Polyposis.ACG case reports journal · 2013Article
- Systematic pancreatic stenting after endoscopic snare papillectomy may reduce the risk of postinterventional pancreatitis.Surgical endoscopy · 2013Article
- Endoscopic papillectomy for benign ampullary neoplasms: how can treatment outcome be predicted?Gut and liver · 2013Article
- Diagnosis and management of ampullary adenoma: The expanding role of endoscopy.World journal of gastrointestinal endoscopy · 2011Article
- A survey of ampullectomy practices.World journal of gastroenterology · 2009Article
- Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eleven tumors of the ampulla of Vater (5 stage IV and 2 stage II adenocarcinomas, 1 stage II papillary carcinoma, 1 neuroendocrine carcinoma, and 2 adenomas, one with foci of carcinoma) were examined for Ki-ras and p53 gene mutations by single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA fragments. Ki-ras mutations were found in one adenocarcinoma and in the adenoma with foci of carcinoma, both involving mainly the intraduodenal bile duct component of the ampulla. Seven cases showed p53 gene mutations: four advanced-stage adenocarcinomas, the papillary carcinoma, the neuroendocrine carcinoma, and the adenoma with foci of carcinoma. Nuclear accumulation of p53 protein was immunohistochemically detected in the morphologically high-grade areas of the five cancers harboring a p53 gene missense point mutation. The adenomas, the two frame shift-mutated cancers, and the adenomatous and low-grade cancer areas of mutated carcinomas were immunohistochemically negative. Our data suggest that in ampullary neoplasia 1) p53 mutations are common abnormalities associated with the transformation of adenomas and low-grade cancers into morphologically high-grade carcinomas, and 2) Ki-ras mutations are relatively less frequent and might be restricted to tumors originating from the bile duct component of the ampulla.
Indexed as
Identifiers
8475992PMC1886879W1550242275What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.