ArticleProceedings of the National Academy of Sciences of the United States of America1993
Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.Molecular immunology · 2016Article
- The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Molecular and cellular biology · 2009Article
- Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy.PLoS genetics · 2008Article
- Cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.Nucleic acids research · 2004Article
- Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells.Molecular and cellular biology · 2002Article
- The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia.Leukemia · 2002Review
- Multiple sites of replication initiation in the human beta-globin gene locus.Nucleic acids research · 2001Article
- Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator.Molecular and cellular biology · 1999Article
- Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region.Molecular and cellular biology · 1997Article
- The heat shock cognate 80 gene of tomato is flanked by matrix attachment regions.Plant molecular biology · 1996Article
- An element in the endogenous IgH locus stimulates gene targeting in hybridoma cells.Nucleic acids research · 1996Article
- Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells.Journal of virology · 1996Article
- Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.Molecular and cellular biology · 1995Article
- Site-specific initiation of DNA replication in Xenopus egg extract requires nuclear structure.Molecular and cellular biology · 1995Article
- Mapping of replication initiation sites in human ribosomal DNA by nascent-strand abundance analysis.Molecular and cellular biology · 1995Article
- Mapping an initiation region of DNA replication at a single-copy chromosomal locus in Drosophila melanogaster cells by two-dimensional gel methods and PCR-mediated nascent-strand analysis: multiple replication origins in a broad zone.Molecular and cellular biology · 1994Article
- A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locus.Molecular and cellular biology · 1994Article
- A novel DNA replication origin identified in the human heat shock protein 70 gene promoter.Molecular and cellular biology · 1994Article
- Elements in the immunoglobulin heavy-chain enhancer directly regulate simian virus 40 ori-dependent DNA replication.Molecular and cellular biology · 1993Article
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3 authors.
Funding
Abstract
In several animal viruses, enhancers have been implicated in both DNA replication and transcriptional activation. The linkage of the two mechanisms appears intimate, in that common DNA binding factors can be shared. The immunoglobulin heavy chain (Igh) intronic [heavy chain joining region (JH)-mu chain constant region (C mu)] enhancer (E mu) is required for tissue-specific transcription of Igh genes and is essential for somatic recombination of diversity (D) and J segments. We show here that E mu is located at or near an origin of chromosomal DNA replication, which is more active in B lymphocytes than fibroblasts. E mu does not fulfill two criteria demonstrated for some cellular origins. E mu can initiate but not maintain autonomous replicating activity in B cells. E mu is unable to impart early replication timing to a transfected VDJ-C mu Igh locus in B cells. Instead we propose that E mu-associated ori activity contributes to tissue-specific Igh expression through local effects on chromatin structure leading to subsequent accessibility of transcription and/or recombination factors for the enhancer.
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