ArticleProceedings of the National Academy of Sciences of the United States of America1993
Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 167 citations in OpenAlex.
- SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.Genes & diseases · 2022Review
- Matrin 3 in neuromuscular disease: physiology and pathophysiology.JCI insight · 2021Review
- Chemical Decorations of "MARs" Residents in Orchestrating Eukaryotic Gene Regulation.Frontiers in cell and developmental biology · 2020Review
- Mitotic bookmarking: maintaining post-mitotic reprogramming of transcription reactivation.Current molecular biology reports · 2016Article
- Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms.Frontiers in immunology · 2016Review
- Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.Journal of cell science · 2015Article
- Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster.Journal of biosciences · 2011Article
- Live cell imaging of the cancer-related transcription factor RUNX2 during mitotic progression.Journal of cellular physiology · 2011Article
- A mini review of MAR-binding proteins.Molecular biology reports · 2010Review
- Nuclear matrix proteome analysis of Drosophila melanogaster.Molecular & cellular proteomics : MCP · 2010Article
- 1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA.Journal of cellular physiology · 2010Article
- Regulation of bone formation and remodeling by G-protein-coupled receptor 48.Development (Cambridge, England) · 2009Article
- Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states.Gene therapy & molecular biology · 2009Article
- Organization of transcriptional regulatory machinery in nuclear microenvironments: implications for biological control and cancer.Advances in enzyme regulation · 2007Review
- Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.Oncogene · 2004Review
- Engineering gene expression and protein synthesis by modulation of nuclear shape.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization.Molecular and cellular biology · 1999Article
- Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation.Molecular and cellular biology · 1999Article
- Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor.Molecular and cellular biology · 1999Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The nuclear matrix appears to play an important role in developmental gene expression during osteoblast differentiation. To better understand this role, we examined nuclear matrix DNA-binding proteins that are sequence-specific and interact with the osteocalcin gene promoter. Multiple protein-DNA interactions involving two distinct nuclear matrix proteins occur within the 5' regulatory sequences (nt -640 to -430). One of these proteins, NMP-1, is a ubiquitous, cell growth-regulated protein that is related to the transcription factor ATF and resides in both the nuclear matrix and the nonmatrix nuclear compartment. The other protein, NMP-2, is a cell type-specific, 38-kDa promoter factor that recognizes binding sites resembling the consensus site for the CCAAT/enhancer-binding protein C/EBP and is localized exclusively on the nuclear matrix. NMP-1 and NMP-2 each interact with two nuclear matrix protein-binding elements. These elements are present near key regulatory sites of the osteocalcin gene promoter, such as the principal steroid hormone (vitamin D)-responsive sequences. Binding in this region of the osteocalcin gene promoter suggests transient associations with the nuclear matrix that are distinct from the stable interactions of matrix attachment regions. Our results are consistent with involvement of the nuclear matrix in concentrating and/or localizing transcription factors that mediate the basal and steroid hormone responsiveness of osteocalcin gene transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.