ArticlePflugers Archiv : European journal of physiology1993
Regulation and possible physiological role of the Ca(2+)-dependent K+ channel of cortical collecting ducts of the rat.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- Going with the flow: New insights regarding flow induced KPhysiological reports · 2024Review
- An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.American journal of physiology. Cell physiology · 2016Review
- Article
- Novel insights into TRPV4 function in the kidney.Pflugers Archiv : European journal of physiology · 2013Review
- Shear-induced volume decrease in MDCK cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2012Article
- Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD.American journal of physiology. Renal physiology · 2011Article
- Effects of pH on potassium: new explanations for old observations.Journal of the American Society of Nephrology : JASN · 2011Article
- α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells.The EMBO journal · 2010Article
- Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct.Journal of the American Society of Nephrology : JASN · 2009Article
- Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.American journal of physiology. Renal physiology · 2008Article
- Inhibition of MAPK stimulates the Ca2+ -dependent big-conductance K channels in cortical collecting duct.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
- Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.Pflugers Archiv : European journal of physiology · 2003Article
- Apical sorting of a voltage- and Ca2+-activated K+ channel alpha -subunit in Madin-Darby canine kidney cells is independent of N-glycosylation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Ca2+ regulated K+ and non-selective cation channels in the basolateral membrane of rat colonic crypt base cells.Pflugers Archiv : European journal of physiology · 1996Article
- Calcium dynamics and homeostasis in a mathematical model of the principal cell of the cortical collecting tubule.The Journal of general physiology · 1996Article
- Maxi K+ channels in the basolateral membrane of the exocrine frog skin gland regulated by intracellular calcium and pH.Pflugers Archiv : European journal of physiology · 1995Article
- K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase.Pflugers Archiv : European journal of physiology · 1995Article
- Effect of NH4+/NH3 on cytosolic pH and the K+ channels of freshly isolated cells from the thick ascending limb of Henle's loop.Pflugers Archiv : European journal of physiology · 1995Article
- pH dependence of K+ conductances of rat cortical collecting duct principal cells.Pflugers Archiv : European journal of physiology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the luminal membrane of rat cortical collecting duct (CCD) a big Ca(2+)-dependent and a small Ca(2+)-independent K+ channel have been described. Whereas the latter most likely is responsible for the K+ secretion in this nephron segment, the function of the large-conductance K+ channel is unknown. The regulation of this channel and its possible physiological role were examined with the conventional cell-free and the cell-attached nystatin patch-clamp techniques. Patch-clamp recordings were obtained from the luminal membrane of isolated perfused CCD segments and from freshly isolated CCD cells. Intracellular calcium was measured using the calcium-sensitive dye fura-2. The large-conductance K+ channel was strongly voltage- and calcium-dependent. At 3 mumol/l cytosolic Ca2+ activity it was half-maximally activated. At 1 mmol/l it was neither regulated by cytosolic pH nor by ATP. At 1 mumol/l Ca2+ activity the open probability (Po) of this channel was pH-dependent. At pH 7.0 Po was decreased to 4 +/- 2% (n = 9) and at pH 8.5 it was increased to 425 +/- 52% (n = 9) of the control. At this low Ca2+ activity the Po of the channel was reduced by 1 mmol/l ATP to 8 +/- 4% (n = 6). Cell swelling activated the large-conductance K+ channel (n = 14) and hyperpolarized the membrane potential of the cells by 9 +/- 1 mV (n = 23). Intracellular Ca2+ activity increased after hypotonic stress. This increase depended on the extracellular Ca2+ activity.(ABSTRACT TRUNCATED AT 250 WORDS)
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