ArticleJournal of virology1993
Functional motifs of delta antigen essential for RNA binding and replication of hepatitis delta virus.
Article in Journal of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus.Journal of biomedical science · 2018Article
- Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway.Journal of virology · 2010Article
- Clathrin-mediated post-Golgi membrane trafficking in the morphogenesis of hepatitis delta virus.Journal of virology · 2009Article
- Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication.RNA (New York, N.Y.) · 2009Article
- Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway.The Journal of biological chemistry · 2008Article
- Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.Journal of biomedical science · 2006Article
- Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent.Journal of virology · 2005Article
- Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus.Journal of virology · 2005Article
- Interaction and replication activation of genotype I and II hepatitis delta antigens.Journal of virology · 2004Article
- Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen.Journal of virology · 2003Article
- Development and characterisation of recombinant hepatitis delta virus-like particles.Virus genes · 2001Article
- Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity.Journal of virology · 2000Article
- Mov34 protein from mouse brain interacts with the 3' noncoding region of Japanese encephalitis virus.Journal of virology · 2000Article
- Specific interaction between the hepatitis C virus NS5B RNA polymerase and the 3' end of the viral RNA.Journal of virology · 1999Article
- Sequence and structural elements at the 3' terminus of bovine viral diarrhea virus genomic RNA: functional role during RNA replication.Journal of virology · 1999Article
- Local helix content and RNA-binding activity of the N-terminal leucine-repeat region of hepatitis delta antigen.Journal of biomolecular NMR · 1998Article
- Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen.Journal of virology · 1998Article
- RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA.Journal of virology · 1997Article
- Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA.Journal of virology · 1995Article
- Functional domains of delta antigens and viral RNA required for RNA packaging of hepatitis delta virus.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functions of delta antigens (HDAgs) in the replication of hepatitis delta virus (HDV) have been identified previously. The small HDAg acts as a transactivator, whereas the large HDAg has a negative effect on replication. To understand the molecular mechanisms involved in the control of HDV replication, we have established a replication system in Huh-7 cells by cotransfecting a monomeric cDNA genome of HDV and a plasmid encoding the small HDAg. We demonstrate that a leucine repeat in the middle domain of the small HDAg is involved in binding to the HDV genome and transactivation of HDV replication. When the leucine repeat was disrupted by a substitution of valine for leucine at position 115, both RNA-binding and transactivation activity of the small HDAg were abolished. In contrast, the binding and transactivation activities were not affected when Leu-37 and Leu-44 of the small HDAg were replaced by valines. In addition, small and large HDAgs can interact with each other to form protein complexes in vitro. The complex formation that may lead to the trans-dominant negative regulation of large HDAg in HDV replication is mediated by a cryptic signal located between amino acid residues 35 and 65 other than the putative N-terminal leucine zipper motif. Furthermore, an extra 21-amino-acid extension near the N terminus converts the small HDAg into a pseudo-large HDAg with negative regulation activity of HDV replication even though the extreme C-terminal residue is unchanged.
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