ArticleThe Journal of clinical investigation1993
N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 135 citations in OpenAlex.
- Diverging metabolic effects of 2 energy-restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity.The American journal of clinical nutrition · 2022Trial
- DietaryNutrients · 2025Article
- Review
- Controversies in the Use of Omega-3 Fatty Acids to Prevent Atherosclerosis.Current atherosclerosis reports · 2022Review
- Hsp40s play distinct roles during the initial stages of apolipoprotein B biogenesis.Molecular biology of the cell · 2022Article
- Oleoylethanolamide differentially regulates glycerolipid synthesis and lipoprotein secretion in intestine and liver.Journal of lipid research · 2018Article
- Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs?Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Review
- Green fluorescent protein-tagged apolipoprotein E: A useful marker for the study of hepatic lipoprotein egress.Traffic (Copenhagen, Denmark) · 2017Article
- Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
- Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells.Journal of lipid research · 2014Article
- Article
- Article
- Insulin-stimulated degradation of apolipoprotein B100: roles of class II phosphatidylinositol-3-kinase and autophagy.PloS one · 2013Article
- The impact of phospholipid transfer protein (PLTP) on lipoprotein metabolism.Nutrition & metabolism · 2012Article
- Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice.Hepatology (Baltimore, Md.) · 2012Article
- Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.The Journal of biological chemistry · 2012Article
- Fish oil -- how does it reduce plasma triglycerides?Biochimica et biophysica acta · 2012Article
- The degradation of apolipoprotein B100: multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways.Biochimica et biophysica acta · 2012Review
- Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response.Frontiers in physiology · 2012Article
- Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management.European heart journal · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When rat hepatocytes were incubated with albumin complexed to the n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), rather than to oleic acid (OA), the secretion of newly synthesized apoprotein B100 (apoB100) or B48 (apoB48) was reduced, despite stimulation of cellular triglyceride synthesis by all three fatty acids. When pulse-chase studies of apoB synthesis and secretion were performed in the presence of OA, EPA, or DHA, there were no significant changes in the initial synthetic rates of either apoB species. However, during the chase period, the total recovery of labeled apoB100 and apoB48 from the cell and medium was less in the n-3 fatty acid groups, so that by 150 min, approximately half as much labeled apoB was recovered as in the OA group. Overall, the decreased accumulation in medium of labeled apoB in the presence of EPA and DHA could be quantitatively accounted for by increased degradation of intracellular apoB. Thus, in the primary hepatocyte, apoB degradation is not constitutive, but can be regulated by n-3 fatty acids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.