ArticleThe Journal of clinical investigation1993
Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 204 citations in OpenAlex.
- Comprehensive molecular and cellular characterization of endoplasmic reticulum stress-related key genes in renal ischemia/reperfusion injury.Frontiers in immunology · 2024Article
- Identification of CD133eLife · 2023Article
- SerpinB3 as hepatic marker of post-resective shear stress.Updates in surgery · 2023Article
- Modulation of the Immune System Promotes Tissue Regeneration.Molecular biotechnology · 2022Review
- Gene 33/Mig6/ERRFI1, an Adapter Protein with Complex Functions in Cell Biology and Human Diseases.Cells · 2021Review
- Functional compensation precedes recovery of tissue mass following acute liver injury.Nature communications · 2020Article
- Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.Human genomics · 2019Article
- Evaluation of Marine Diindolinonepyrane in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetic Properties in Beagle Dogs.Marine drugs · 2019Article
- Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis.Journal of clinical and translational research · 2018Article
- Transforming growth factor-β in liver cancer stem cells and regeneration.Hepatology communications · 2017Review
- Hepatocyte growth factor and epidermal growth factor activity during later stages of rat liver regeneration upon interferon α-2b influence.Clinical and experimental hepatology · 2017Article
- Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy.World journal of gastroenterology · 2016Review
- The effect of silymarin on hepatic regeneration after partial hepatectomy: is silymarin effective in hepatic regeneration?International journal of clinical and experimental medicine · 2015Article
- DNA methylation dynamics in the rat EGF gene promoter after partial hepatectomy.Genetics and molecular biology · 2014Article
- Liver regeneration.Translational research : the journal of laboratory and clinical medicine · 2014Review
- Chronic ethanol feeding alters miRNA expression dynamics during liver regeneration.Alcoholism, clinical and experimental research · 2013Article
- Article
- G1 cell cycle arrest signaling in hepatic injury after intraperitoneal sepsis in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Reference gene selection for real-time RT-PCR in eight kinds of rat regenerating hepatic cells.Molecular biotechnology · 2010Article
- ATF3-mediated epigenetic regulation protects against acute kidney injury.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Liver regeneration is an important process that allows for recovery from hepatic injuries caused by viruses, toxins, ischemia, surgery, and transplantation. Previously, we identified > 70 immediate-early genes induced in regenerating liver after hepatectomy, 41 of which were novel. While it is expected that the proteins encoded by these genes may have important roles in regulating progression through the G1 phase of the cell cycle during regeneration, we were surprised to note that many of these "early" genes are expressed for extended periods during the hepatic growth response. Here we define several patterns of expression of immediate-early, delayed-early, and liver-specific genes during the 9-d period after hepatectomy. One pattern of induction parallels the major growth period of the liver that ends at 60-72 h after hepatectomy. A second pattern has two peaks coincident with the first and second G1 phases of the two hepatic cell cycles. A third group, which includes liver-specific genes such as C/EBP alpha, shows maximal expression after the growth period. Although the peak in DNA synthesis in nonparenchymal cells occur 24 h later than in hepatocytes, most of the genes studied demonstrate similar induction in both cell types. This finding suggests that the G0/G1 transition occurs simultaneously in all cells in the liver, but that the G1 phase of nonparenchymal cells may be relatively prolonged. Finally, we examined the expression of > 70 genes in clinical settings that could induce liver regeneration, including after perfusion in a donor liver, hepatic ischemia, and fulminant hepatic failure. We found that a small number of early and liver-specific genes were selectively activated in human livers under these conditions, and we thereby provide a potential means of measuring the caliber of the regenerative response in clinical situations.
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