ArticleImmunology1993
IgE and IgG2a antibody responses are induced by different antigen groups of the nematode Nippostrongylus brasiliensis in rats.
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- A modified hybridoma technique for production of monoclonal antibodies having desired isotypes.Cytotechnology · 2009Article
- Up-regulation of Fas (CD95) and induction of apoptosis in intestinal epithelial cells by nematode-derived molecules.Infection and immunity · 2002Article
- Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model.Infection and immunity · 2002Article
- Suppression of gamma interferon transcription and production by nematode excretory-secretory antigen during polyclonal stimulation of rat lymph node T cells.Infection and immunity · 2000Article
- Cysteine protease of the nematode Nippostrongylus brasiliensis preferentially evokes an IgE/IgG1 antibody response in rats.Clinical and experimental immunology · 1995Article
- Immunocytochemical localization of secretory acetylcholinesterase of the parasitic nematode Nippostrongylus brasiliensis.Cell and tissue research · 1995Article
- Article
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- Dissociation of specific and total IgE antibody responses following repeated low-level infections with Nippostrongylus brasiliensis in rats.Clinical and experimental immunology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differences were examined between IgE, IgG1 and IgG2a antibody responses against two kinds of nematode antigens in rats infected with Nippostrongylus brasiliensis. With ELISA studies, remarkable IgE and IgG1 antibody responses were observed against antigens in excretory/secretory products (ES) of N. brasiliensis, whereas the IgG2a antibody response against ES was negligible. On the other hand, antibody response to antigens in an extract of homogenized adult worm (AW) was observed mainly in IgG2a, with little response in IgE or IgG1. Immunohistochemical studies showed that IgE- and IgG1-binding antigens were localized almost exclusively in the subventral glands, a secretory apparatus in N. brasiliensis, while IgG2a-binding antigens were found mainly in the nematode wall along the body cavity. Immunoblot analysis revealed that the major IgE- and IgG1-binding molecules in ES were identical. On the other hand, some, but not all, of the major IgG2a-binding molecules in AW were different from the IgE/IgG1-binding molecules in ES. The findings suggest that the IgE/IgG1 and IgG2a antibody responses in N. brasiliensis-infected rats are induced by different groups of nematode antigens. Thus, it is presumed that the production of each class of antibody might be dependent, at least in part, on the nature of the antigen or antigen-linked molecules.
Indexed as
Identifiers
8473018PMC1421812W285024814What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.