ArticleThe Journal of cell biology1993
Apical polarization of N-CAM in retinal pigment epithelium is dependent on contact with the neural retina.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems.Progress in retinal and eye research · 2021Review
- Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking.International journal of molecular sciences · 2021Review
- Retinal pigment epithelium polarity in health and blinding diseases.Current opinion in cell biology · 2020Review
- Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.Experimental eye research · 2014Review
- Trafficking to the apical and basolateral membranes in polarized epithelial cells.Journal of the American Society of Nephrology : JASN · 2014Review
- ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.Journal of molecular neuroscience : MN · 2012Article
- Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.Advances in experimental medicine and biology · 2010Article
- The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration.Trends in molecular medicine · 2009Article
- Epithelial phenotype and the RPE: is the answer blowing in the Wnt?Progress in retinal and eye research · 2008Review
- Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.American journal of physiology. Cell physiology · 2006Article
- The retinal pigment epithelium apical microvilli and retinal function.Advances in experimental medicine and biology · 2006Review
- The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium.Molecular biology of the cell · 2004Article
- Analysis of retinal pigment epithelium integrin expression and adhesion to aged submacular human Bruch's membrane.Transactions of the American Ophthalmological Society · 2003Article
- Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium.The Journal of cell biology · 1999Article
- Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation.The Journal of cell biology · 1999Article
- Apical polarity of N-CAM and EMMPRIN in retinal pigment epithelium resulting from suppression of basolateral signal recognition.The Journal of cell biology · 1998Article
- The effect of apical and basolateral lipids on the function of the band 3 anion exchange protein.The Journal of cell biology · 1997Article
- Spatially restricted increase in polysialic acid enhances corticospinal axon branching related to target recognition and innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.The Journal of cell biology · 1995Article
- The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2.The Journal of clinical investigation · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The retinal pigment epithelium (RPE) is unique among epithelia in that its apical surface does not face a lumen, but, instead, is specialized for interaction with the neural retina. The molecules involved in the interaction of the RPE with the neural retina are not known. We show here that the neural cell adhesion molecule (N-CAM) is found both on the apical surface of RPE in situ and on the outer segments of photoreceptors, fulfilling an important requisite for an adhesion role between both structures. Strikingly, culture of RPE results in rapid redistribution of N-CAM to the basolateral surface. This is not due to an isoform shift, since the N-CAM expressed by cultured cells (140 kD) is the same as that expressed by RPE in vivo. Rather, the reversed polarity of N-CAM appears to result from the disruption of the contact between the RPE and the photoreceptors of the neural retina. We suggest that N-CAM in RPE and photoreceptors participate in these interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.