ArticleHistochemistry1993
Molecular heterogeneity of the actin filament cytoskeleton associated with microvilli of photoreceptors, Müller's glial cells and pigment epithelial cells of the retina.
Article in Histochemistry, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE.Investigative ophthalmology & visual science · 2025Article
- Photoreceptor calyceal processes accompany the developing outer segment, adopting a stable length despite a dynamic core.Journal of cell science · 2024Article
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.International journal of molecular sciences · 2019Review
- Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.Investigative ophthalmology & visual science · 2016Article
- Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice.Experimental eye research · 2015Article
- Beyond polarity: functional membrane domains in astrocytes and Müller cells.Neurochemical research · 2012Review
- Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice.The Journal of cell biology · 2012Article
- Expression and role of VEGF in the adult retinal pigment epithelium.Investigative ophthalmology & visual science · 2011Article
- The retinal pigment epithelium apical microvilli and retinal function.Advances in experimental medicine and biology · 2006Review
- Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus.Molecular biology of the cell · 2003Article
- Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium.The Journal of cell biology · 1999Article
- Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.The Journal of cell biology · 1995Article
- Colocalization of cytokeratin 18 and villin in type III alveolar cells (brush cells) of the rat lung.Histochemistry · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study addressed the question as to whether the four different actin-associated proteins that are associated with the actin core bundle in intestinal microvilli (i.e. villin, fimbrin, myosin I and ezrin) are essential components of all microvilli of the body. The retina provides an excellent example of a tissue supplied with three different sets of microvilli, namely those of Müller's glial cells (Müller baskets), photoreceptors (calycal processes), and pigment epithelial cells. The main outcome of this study is that none of these microvilli contain all four actin-associated proteins present in intestinal microvilli. Müller cell microvilli contain villin, ezrin and myosin I (95 kDa isoform) but not fimbrin. Calycal processes of photoreceptors contain fimbrin but not villin, myosin I and ezrin. Finally, microvilli of pigment epithelial cells are positive for ezrin but not for villin, fimbrin and myosin I. Because of limited cross-reactivities of the antibodies to myosin I and ezrin, the myosin I data refer to the chicken retina whereas the findings with anti-ezrin were obtained with the rat retina. A further outcome of this study is that the actin filament core bundles in microvilli of chicken pigment epithelial cells are presumed to contain a crosslinking protein, which is not immunologically related to either villin, fimbrin or myosin I of the intestinal brush border.
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