ArticleThe EMBO journal1993
Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 84 citations in OpenAlex.
- Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development.Development, growth & differentiation · 2024Article
- Article
- COUP-TFs and eye development.Biochimica et biophysica acta · 2015Review
- Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo.PloS one · 2014Article
- Regulatory potential of COUP-TFs in development: stem/progenitor cells.Seminars in cell & developmental biology · 2013Review
- Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns.BMC evolutionary biology · 2009Article
- Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.The Journal of biological chemistry · 1999Article
- The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development.Genes & development · 1999Article
- UNC-55, an orphan nuclear hormone receptor, orchestrates synaptic specificity among two classes of motor neurons in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Functional domains of the human orphan receptor ARP-1/COUP-TFII involved in active repression and transrepression.Molecular and cellular biology · 1997Article
- The nuclear orphan receptors COUP-TF and ARP-1 positively regulate the trout estrogen receptor gene through enhancing autoregulation.Molecular and cellular biology · 1997Article
- Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.Molecular and cellular biology · 1996Article
- COUP-TF II homodimers are formed in preference to heterodimers with RXR alpha or TR beta in intact cells.Nucleic acids research · 1995Article
- Convergent evolution of crystallin gene regulation in squid and chicken: the AP-1/ARE connection.Journal of molecular evolution · 1994Article
- Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.Molecular and cellular biology · 1994Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several members of the steroid receptor superfamily, including the transcription factor COUP, are closely related to the Drosophila gene seven-up (svp) which is required for the development of the embryonic central nervous system (CNS) and specific photoreceptor cells of the eye. We have identified and characterized two zebrafish (Brachydanio rerio) members of this subfamily of orphan nuclear receptors. While one of them (svp[44]) is the zebrafish cognate of COUP, the second (svp[46]) seems to be a novel member of the COUP/svp group. The proteins encoded by both genes contain highly conserved DNA-binding and putative ligand-binding domains, indicating close similarities in target sequence recognition and ligand binding. Analysis of the spatial distribution of their transcripts in whole-mount embryos revealed that the CNS is a major site of expression for both genes. At early embryonic stages, both genes are expressed in domains corresponding to specific rhombomere primordia in the hindbrain. This suggests an involvement in hindbrain segmentation and/or rhombomere specification. Moreover, transcripts derived from both genes are detected within distinct areas of the eye rudiments, suggesting roles in eye patterning and/or cell differentiation. In the case of the svp[44] gene, expression is also observed within specific parts of the midbrain, diencephalon and telencephalon. These results represent the first evidence that at least some of the nervous system and eye-specific functions of Drosophila svp are conserved in vertebrates.
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