ArticleClinical and experimental immunology1993
Abnormalities of the IgA immune system in members of unrelated pedigrees from patients with IgA nephropathy.
Article in Clinical and experimental immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Shared genetics of IgA nephropathy and cardiometabolic diseases revealed by integrative genomic analysis.Renal failure · 2026Article
- Review
- Inflammation in IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2017Review
- Mesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1.BMC nephrology · 2016Article
- New developments in the genetics, pathogenesis, and therapy of IgA nephropathy.Kidney international · 2015Review
- The Genetics of IgA Nephropathy: An Overview from Western Countries.Kidney diseases (Basel, Switzerland) · 2015Review
- Genetic studies of IgA nephropathy: past, present, and future.Pediatric nephrology (Berlin, Germany) · 2010Review
- Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy.Journal of the American Society of Nephrology : JASN · 2008Article
- Immunopathogenesis of IgAN.Seminars in immunopathology · 2007Review
- Profiles of immunoregulatory cytokine production in vitro in patients with IgA nephropathy and their kindred.Clinical and experimental immunology · 1994Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last few years many investigators have reported the recurrence of primary IgA nephropathy (IgAN) or the presence of persistent microhaematuria and/or proteinuria in family members of patients with IgAN. Our study was undertaken to investigate the relevance of abnormalities in the regulation of the IgA and IgM immune system in microhaematuric and asymptomatic family members of IgAN patients. Fifty-four out of 120 members of nine unrelated pedigrees were examined by urinalysis; polymeric IgA (pIgA), IgA rheumatoid factor (IgARF), IgA1-IgG immune complexes (IgA 1-IgG IC) and IgA 1-IgM IC, and other immunoglobulins were measured in serum samples. Moreover, we studied the production of immunoglobulins, pIgA and IgARF by peripheral blood mononuclear cells (PBMC) in basal conditions and after pokeweed mitogen (PWM) stimulation. Our data demonstrate that persistent microhaematuria was present in 24% of relatives. High serum levels of IgA, mainly pIgA and IgARF, IgA 1-IgG IC and IgA 1-IgM IC occurred in 66% of relatives. Abnormal spontaneous production of IgA by PBMC and after PWM stimulation was present in 64% of family members. Interestingly, high serum levels of IgM and abnormal production of this immunoglobulin by PBMC were observed in relatives. However, the immunological abnormalities did not correlate in any way with the presence of urinary abnormalities such as microhaematuria, which was most likely determined by an underlying glomerular alteration.
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