Trial reportArchives of disease in childhood1993
Treatment of croup with nebulised steroid (budesonide): a double blind, placebo controlled study.
Trial report in Archives of disease in childhood, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Glucocorticoids for croup in children.The Cochrane database of systematic reviews · 2023Pooled it
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Glucocorticoids for croup in children.The Cochrane database of systematic reviews · 2018Pooled it
- Nebulized epinephrine for croup in children.The Cochrane database of systematic reviews · 2013Pooled it
- Nebulised steroid in the treatment of croup: a systematic review of randomised controlled trials.The British journal of general practice : the journal of the Royal College of General Practitioners · 2000Pooled it
- Role of steroids in croup and beta agonists in bronchiolitis.Indian journal of pediatricsPooled it
- Double blind placebo controlled trial of nebulised budesonide for croup.Archives of disease in childhood · 1997Trial
- Efficacy of a small single dose of oral dexamethasone for outpatient croup: a double blind placebo controlled clinical trial.BMJ (Clinical research ed.) · 1996Trial
- Review
- Influence of Physicochemical Properties of Budesonide Micro-Suspensions on Their Expected Lung Delivery Using a Vibrating Mesh Nebulizer.Pharmaceutics · 2023Article
- Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases.Italian journal of pediatrics · 2021Article
- Severe upper airway obstruction following bilateral ventral bulla osteotomy in a cat.The Canadian veterinary journal = La revue veterinaire canadienne · 2017Article
- Article
- Management of croup.Paediatric drugs · 2002Review
- Interobserver variability of croup scoring in clinical practice.Paediatrics & child health · 2001Article
- Review
- Role of steroids in treatment of croup.Indian journal of pediatrics · 2000Article
- Pathogenesis of lower respiratory tract infections due to Chlamydia, Mycoplasma, Legionella and viruses.Thorax · 1998Review
- Nebuliser therapy in childhood.Thorax · 1997Review
- A risk-benefit assessment of corticosteroids in the management of croup.Drug safety · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this prospective, randomised, double blind study was to evaluate whether nebulised local steroid treatment is effective in the treatment of croup. Thirty six infants and children (0.4-4.9 years of age) admitted to hospital with moderate to severe croup were allocated to receive either 2 mg nebulised budesonide (20 children) or saline (16 children). Disease severity was assessed by a clinical total croup score based on stridor, cough, retractions, dyspnoea, and cyanosis. In addition the overall clinical impression was evaluated (0-100). Two hours after treatment there was a significant improvement in the total croup score in the group treated with budesonide (8 to 4.5), but not in the group treated with saline (8 to 8). Furthermore, the overall clinical impression assessment score decreased significantly (50 to 25) in the group treated with budesonide, whereas it remained constant in the placebo group (60 to 62). The total croup score and overall clinical severity were significantly better in the group treated with budesonide than in the placebo group. No side effects were observed. The results indicate that nebulised budesonide can be used as a safe and effective alternative treatment in children and infants with moderate to severe croup.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.