ArticleVirchows Archiv. A, Pathological anatomy and histopathology1993
Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 54 citations in OpenAlex.
- Hepatic stellate cells in liver fibrosis: From biology to pathology.Open veterinary journal · 2025Review
- Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CClLiver international : official journal of the International Association for the Study of the Liver · 2025Article
- Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma.Journal of hepatocellular carcinoma · 2014Review
- Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model.Digestive diseases and sciences · 2013Article
- Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.Physiological reviews · 2008Review
- Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA.Molecular and cellular biology · 1999Article
- The hepatic stellate (Ito) cell: its role in human liver disease.Virchows Archiv : an international journal of pathology · 1997Review
- Apoptosis participates in cellularity regulation during rat aortic intimal thickening.The American journal of pathology · 1995Article
- Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis.Virchows Archiv : an international journal of pathology · 1995Article
- Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity.Virchows Archiv : an international journal of pathology · 1994Review
- Hepatic stellate cells - from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic perisinusoidal cells (PSCs) proliferate and are thought to be the principal source of extracellular matrix proteins during the development of liver fibrosis. We have studied the classical model of carbon tetrachloride induced liver fibrosis in order to evaluate the possible modulation of PSCs into a synthetically active and contractile cell: the myofibroblast (MF). At the ultrastructural level, this modulation was characterized by reduction of lipid vacuoles and appearance of a developed rough endoplasmic reticulum as well as of microfilament bundles. On investigating the cytoskeletal equipment of PSCs and MFs using light and electron microscopic immunohistochemistry, we found a heterogeneity of phenotypic features. While typical PSCs in normal and fibrotic livers always contained desmin, MFs expressed alpha-smooth muscle (SM) actin in areas of tissue injury and active fibrogenesis. Cells co-expressing alpha-SM actin and desmin were most prominent in the prevenular zone of the lobule (known to be vulnerable to carbon tetrachloride toxicity) and in developing fibrous septa. As demonstrated by immunogold electron microscopy, labelling of microfilament bundles by alpha-SM actin antibody was noted in PSCs containing lipid droplets in early stages of fibrosis; here MFs gradually accumulated and showed alpha-SM actin containing microfilament bundles. In scar tissue, alpha-SM actin expression decreased in both PSCs and myofibroblasts. Our observations support the concept of phenotypic plasticity of PSCs and confirm, at the ultrastructural level, previous suggestions of modulation of these cells into MFs in the course of liver fibrosis.
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